Antioxidant, Antimicrobial Properties and In Silico Study of a N,N`-(ethane-1,2-diyl)bis(1-(9H-fluoren-2-yl)methanimine)

Authors : İlter DEMİRHAN, Erkan ÖNER, Adem NECİP, Aydın AKTAŞ, Medine ÇOTAK, Yetkin GÖK

Pages : 459-479

Doi:10.38001/ijlsb.1097396

View : 20 | Download : 5

Publication Date : 2022-12-15

Article Type : Research Paper

Abstract :ABSTRACT This study aimed to determine the antibacterial and antioxidant activities of the newly synthesized Schiff base and to support the laboratory results with molecular modeling studies. Antibacterial activity of schiff bases was demonstrated using Gram insert ignore into journalissuearticles values(-); Pseudomonas aeruginosa and Acinetobacter baumannii bacterial strains. Minimum Inhibition Concentration insert ignore into journalissuearticles values(MIC); values were determined to evaluate their antimicrobial activity against Gram-negative P. aeruginosa and A.baumanni bacterial strains. In antioxidant experiments, the responses to DPPH and ABTS radicals were calculated at certain concentration ranges and graphs were drawn. For the molecular modeling study, Autodock Vina and Discovery Studio 2020 package programs were used. The observed bacterial inhibition activity was variable depending on the clinical isolate and the concentration of the tested samples. The highest inhibition activity was achieved at concentration of 75 μl -100 μl. N,N\`-insert ignore into journalissuearticles values(ethane-1,2-diyl);bisinsert ignore into journalissuearticles values(1-insert ignore into journalissuearticles values(9H-fluoren-2-yl);methanimine); samples. Molecular docking results show that N,N\`-insert ignore into journalissuearticles values(ethane-1,2-diyl);bisinsert ignore into journalissuearticles values(1insert ignore into journalissuearticles values(9H-fluoren-2-yl); methanimine); binds strongly to the 4ZIY and 4ZHU structures. It has been proven by molecular docking study that the synthesized Schiff base ligand has antibiotic resistance properties. N, N\`-insert ignore into journalissuearticles values(ethane-1,2-diyl);bisinsert ignore into journalissuearticles values(1-insert ignore into journalissuearticles values(9Hfluoren-2-yl); methanimine); synthesis compound showed moderate activity against A. baumannii and P. aeruginosa strains. It is known that schiff bases have strong biological activities and show antibacterial activity. In this study, it can be said that the synthesis schiff base showed antibacterial and antioxidant activity. In addition, our results were supported by molecular modeling. Our findings can be taken to a higher level with in vivo and in vitro studies.
Keywords : schiff bases, antioxidant, In silico, molecular docking, antimicrobial