Investigation of Some Corticosteroids as Glutathione Reductase Inhibitor

Authors : Esra ŞENTÜRK, Murat ŞENTÜRK

Pages : 119-125

Doi:10.21448/ijsm.693816

View : 13 | Download : 5

Publication Date : 2020-06-13

Article Type : Research Paper

Abstract :The detection of glutathione reductase inhibitors insert ignore into journalissuearticles values(GRIs); has recently become very popular due to their use as malarial and cancer drugs. Today, steroidal compounds have several clinical roles due to their potent immunomodulating and anti-inflammatory properties. In this study, GR inhibitory capacity of some corticosteroids insert ignore into journalissuearticles values(dexamethasone, prednisolone and methylprednisolone); has been reported. Amongst these steroidal molecules dexamethasone showed the weakest inhibitory effect on GR enzyme. IC50 values were determined by drawing % activity-[I] graphs for these corticosteroids showing inhibition effects. These corticosteroids have inhibition ranging micromolar for GR with IC50 values. These corticosteroids exhibit very potent inhibitory activity against GR enzyme at low micromolar concentrations when compared to well-known GRIs.
Keywords : Steroid, Glutathione reductase, Inhibition, Oxidative stress, Cancer