Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer

Authors : Ebru DEVECİ, Gülsen TEL-ÇAYAN, Serdar KARAKURT, Mehmet Emin DURU

Pages : 40-48

Doi:10.21448/ijsm.793715

View : 14 | Download : 11

Publication Date : 2021-03-08

Article Type : Research Paper

Abstract :Porodaedalea pini is a medicinally important mushroom with antioxidant, cytotoxic, immunostimulating, antitumor, antiviral and immunomodulating activities. Therefore, in this study, P. pini methanol extract and isolated compounds from the methanol extract were tested for cytotoxic activities against DLD-1 insert ignore into journalissuearticles values(colorectal cancer); and CCD-18Co insert ignore into journalissuearticles values(human colon fibroblast cell line); by using Alamar Blue assay. Cytotoxic activity on DLD-1 was decreased in the order of P. pini methanol extract> 4-insert ignore into journalissuearticles values(3,4-dihydroxyphenyl);but-3-en-2-one insert ignore into journalissuearticles values(3);> pinoresinol insert ignore into journalissuearticles values(2);> ergosta-7,24insert ignore into journalissuearticles values(28);-dien-3β-ol insert ignore into journalissuearticles values(1);. P. pini methanol extract was determined to have the best cytotoxic activity with the lowest IC50 value on DLD-1 insert ignore into journalissuearticles values(IC50: 25.33±0.29 µg/mL); and the highest IC50 value on CCD-18Co insert ignore into journalissuearticles values(434.30±1.45 µg/mL);. Within the scope of the findings, it is thought that P. pini mushroom can be used as a new and natural agent in the treatment of colorectal cancer.
Keywords : Porodaedalea pini, Colorectal cancer, Cytotoxic activity, Extract, Isolation