Evaluation of Acute and Subacute Toxicity of ISY-CP® Food Herbal Mixture in Rats

Authors : Mustafa YAŞAR, Oğuzhan ŞENOĞUL, Beste KARADENİZ, Ali GÖK, Pınar AĞYAR YOLDAŞ, Kağan AĞAN

Pages : 54-60

View : 19 | Download : 11

Publication Date : 2020-08-27

Article Type : Research Paper

Abstract :Objective: Recently, there is a growing interest in medicinal and aromatic plants also the treatment methods by using these plants in traditional and complementary medicine. On the other hand, possible toxicities of medicinal and aromatic plants has lately begun to be researched and it is extremely important to cognize these possibilities for human consumption. Therefore, a research has been conducted to understand the acute/subacute toxicity characteristics of a plant based herbal mixture, ISY-CP® used in remember regeneration therapy method insert ignore into journalissuearticles values(RTM); in rats. The product contains a mixture of nettle leaves insert ignore into journalissuearticles values(Urtica dioica);, yarrow insert ignore into journalissuearticles values(Achillea millefolium);, thyme insert ignore into journalissuearticles values(Thymus vulgaris); and horsetail insert ignore into journalissuearticles values(Equisetum arvense); plants. The aim of this research was to examine the effects of ISY-CP® herbal mixture in term of toxicity. Material-Method: In the experimental design, 32 female rats were divided into 4 groups insert ignore into journalissuearticles values(control, acute, subacute and post-subacute);. In order to observe acute and subacute toxicity, clinical observations were performed and the biochemical, hematological and histopathological parameters of the animals were evaluated at the end of the application. Results: According to the results obtained from the study, there were not found significant differences in biochemical, hematological and histopathological evaluations between the control and the application groups. Only phorphorus data is statistically different between subacute toxicity group and control group. Conclusion: In our study, the acute and subacute toxic effects of ISY-CP® herbal mixture’s doses used in this study were not observed.
Keywords : Traditional and complementary medicine, acute toxicity, subacute toxicity, Urtica dioica, Achillea millefolium, Thymus vulgaris, Equisetum arvense