Chemical Structure and Synthesis of Baloxavir Marboxil, A Novel Endonuclease Inhibitor For The Treatment Influenza : An Overview

Authors : Amine Sena AYDIN, Halise İnci GÜL

Pages : 20-27

View : 11 | Download : 8

Publication Date : 2022-07-06

Article Type : Review Paper

Abstract :One drug target that was identifed as a promising candidate for infuenza antiviral drugs is the infuenza virus polymerase complex. The three-component polymerase complex, which is highly conserved and is essential for infuenza virus replication, has received considerable attention as a potential target for infuenza antiviral drugs. Baloxavir marboxil insert ignore into journalissuearticles values(Xofuza®; hereafter referred to as baloxavir);, the prodrug of baloxavir acid, is a frst-in-class, small molecule inhibitor of the cap-dependent endonuclease reaction that is conducted by the polymerase acidic insert ignore into journalissuearticles values(PA); protein subunit of the infuenza virus polymerase complex. In this review, we summarized the chemical structure, synthesis, mechanism of action, pharmacological activity and synthesis of Baloxavir marboxil, a novel FDA-approved endonuclease inhibitor for the treatment of influenza.
Keywords : Antiviral, baloxavir marboxil, endonuclease inhibitor, influenza, synthesis