- International Journal of PharmATA
- Volume:2 Issue:1
- Covid-19 and Antiviral Drugs Used In Its Treatment
Covid-19 and Antiviral Drugs Used In Its Treatment
Authors : Büşra YÜKSEL, Yücel KADIOĞLU
Pages : 25-29
View : 9 | Download : 5
Publication Date : 2022-01-25
Article Type : Review Paper
Abstract :The new coronavirus, the seventh family member of β coronaviruses, entered our lives as 2019-nCoV. The first outbreak was seen in December 2019 in Wuhan, China. It has been reported as a zoonotic disease. 2019-nCoV; causes fatal diseases affecting the lungs, heart, liver and the whole body. 2019-nCoV interacts with ACE-2 and infects epithelial cells, initiating endothelial activation, localized inflammation, tissue damage, and dysregulated cytokine release. Antiviral drugs that selectively bind to viral proteases block the proteolytic cleavage of protein precursors necessary to produce infectious, thereby preventing viral replication. Newly designed antiviral drugs act not on viral entry into host cells but instead by blocking one or more steps of virus replication within the cell. Appropriate analytical methods are required to monitor the precise amount, distribution, metabolism, adsorption and elimination of these drugsand their metabolites in biofluids and tissues. These methods are; The preparation of plasma samples includes protein precipitation insert ignore into journalissuearticles values(PP);, solid phase extraction insert ignore into journalissuearticles values(SPE);, liquid-liquid extraction insert ignore into journalissuearticles values(LLE);, or a combination of two or more of these.Keywords : Antiviral drugs, extraction, Sars Cov 2