Evaluation of Rt-PCR Cycle Threshold Values of SARS-CoV-2 and epidemiological datas of COVID-19 patients

Authors : Yeliz TANRIVERDİ ÇAYCI, Gülşah KARACAN, Aynur ATİLLA, Özkan YAŞAYANCAN, Demet GÜR VURAL, Kemal BİLGİN, Asuman BIRINCI, Emine Hafize ERDENİZ

Pages : 127-133

Doi:10.34084/bshr.1313826

View : 47 | Download : 42

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Introduction: COVID-19 infection is diagnosed by RT-PCR. In this test results interpreted according to the cycle threshold insert ignore into journalissuearticles values(Ct); values, provide indirect measurements of viral load. In this study we aimed to the evalaute the relationship between Ct values and demographics and sypmtoms of patients. Material and Methods: The nasopharyngeal swab of the patients suspected with COVID-19 were collected and tested by RT-PCR for SARS-CoV-2. Demographics, medical history, timelines for exposure and symptoms of the patients diagnosed as COVID-19 by RT-PCRwere obtained from the hospital information system. Results: Total of 619 patient result was enrolled in the study. Ct values were determined as 24.74 insert ignore into journalissuearticles values(20.95-27.64); for 18> years-old and 22.85 insert ignore into journalissuearticles values(20.14-26.22); ≥18 years-old, there was no statistically difference according to the age among Ct values. Hypertension was the most common comorbid disease insert ignore into journalissuearticles values(13.3%); among COVID-19 patients. A positive correlation was detected among the onset of the symptoms and Ct values, Ct values were lowest insert ignore into journalissuearticles values(corresponding to a higher viral RNA concentration); soon after symptom onset. Patients who had fever, headache, muscle-joint pain significantly had lower Ct values were than patients who did not have these sypmtoms. Conclusion: It is important to early testing for SARS-CoV-2 among persons who have respiratory symptoms, and isolation of them when their viral load and transmission rate is higher.
Keywords : Sars Cov2, Döngü eşik değeri, COVID 19, epidemiyoloji