Prevalence and Antimicrobial Susceptibility Pattern of Staphylococcus species causing Urinary Tract Infections in Women of Reproductive Age: 5 Years Retrospective Study

Authors : Sondos A. A. Ibnouf, Sait Ramazan Gülbay, Metin Dogan

Pages : 231-238

Doi:10.34084/bshr.1335699

View : 45 | Download : 67

Publication Date : 2023-12-31

Article Type : Research Paper

Abstract :Background/Aim: Infections of the urinary tract are amongst the most prevalent infections in women, females at child-bearing age have a higher predisposition to urinary tract infections. Approximately 13% of health-care-associated urinary tract infections occur due to Coagulase Negative Staphylococci (CNS); this species’ resistance rate is alarming. The study aims to describe urinary tract infections of women of reproductive age through 5 years of results, emphasizing Staphylococcus species as an etiological agent and their antimicrobial susceptibility patterns. Material and Methods: In the study, 4562 urine samples sent between November 2017 and November 2022 were retrospectively analyzed. Routine culture methods were used to isolate bacteria from urine specimens. According to the European Committee on Antimicrobial Susceptibility Testing (version 8.0-12.0) recommendations, an antimicrobial susceptibility test was performed using the disc diffusion technique. Obtained data analysis was achieved by Statistical Package for Social Sciences (SPSS 20.0), Categorical variables were presented as frequency and percentage however continuous variable was described as mean ± Standard deviation (SD), and binary logistic regression test was done to determine the association with statistical significance of (p<0.05). Results: Of the 4562 urine samples taken from women of reproductive age, 166 (3.6%) had a UTI due to Staphylococcus species. The most common species was CNS 110 (66.2%). Followed by, Staphylococcus aureus which was 42 (25.3%), and Staphylococcus saprophyticus 14 (8.4%). All isolate species showed susceptibility to tigecycline and linezolid (100%). The highest level of antibiotic resistance was showed by S. aureus and CNS against penicillin-G which was (83.30%) and (58.1%) respectively, while the majority of S. saprophyticus showed resistance against Erythromycin (64.2%). CNS displayed the highest oxacillin resistance (20.90%) among Staphylococcus species. Conclusion: The study illustrates the significance of Staphylococcus species as a pathogen of the urinary tract, especially in women of reproductive age. There is clear evidence of the resistance of isolates to penicillin-G which may suggest the production of penicillin-binding protein 2a. Regular surveillance of the frequency and resistance pattern of Staphylococcus species causing urinary tract infections in local regions, especially keeping in mind the high-risk patients mentioned in our study should be monitored.
Keywords : Doğurgan çağ, idrar yolu enfeksiyonu, kadınlar, Stafilokok Suşları