Identification of serotonergic 5HT-3B type receptors in broiler’s small intestine

Authors : İndira MUJEZİNOVİĆ, Muhamed KATİCA, Ahmed SMAJLOVİĆ, Nedžad GRADAŠČEVİĆ, Behija DUKİĆ

Pages : 8-13

Doi:10.30704/http-www-jivs-net.404248

View : 11 | Download : 9

Publication Date : 2018-04-30

Article Type : Research Paper

Abstract :in broiler’s small intestine. Investigation were carried out on isolated smooth muscle of the circular and longitudinal layer of the broilers small intestine insert ignore into journalissuearticles values(strip dimension 3-4 mm x 2 cm);. The muscle strips were placed in an isolated organ bath. The mechanical activity of the preparations were recorded via an isotonic force transducer coupled to a pen recorder. This was done following the addition of serotonin insert ignore into journalissuearticles values(nonselective 5-HT agonist);, 2-Me-5HT insert ignore into journalissuearticles values(5-HT3B agonist); and Y-25130-hydrochloride insert ignore into journalissuearticles values(selective 5-HT3B antagonist);. The research established a presence of serotonergic 5HT3B type receptors within the smooth musculature of the small intestines of broilers insert ignore into journalissuearticles values(COBB 500);. The 5HT3B type receptors were present in smooth muscles of duodenum, jejunum and ileum, especially in longitudinal smooth muscles since this layer reacted even to low serotonin concentration insert ignore into journalissuearticles values(10-6);. Statistical tests of obtained results showed significant differences insert ignore into journalissuearticles values(p< 0.001); in responses related to muscle layers, applied concentrations and intestinal parts which were observed. In the light of these findings, we suggest that investigated substances may have considerable physiological and therapeutic implications in disturbed function of small intestine of broiler’s.
Keywords : Broilers, serotonin, serotonergic receptors, isolated smooth muscle, small intestine