The effect of coenzyme Q10 on blood plasma nitric oxide and total antioxidant capacity levels in hypothyroidism-induced rats

Authors : Cemşah YAZICI, Tufan KEÇECİ, Durmuş HATİPOĞLU

Pages : 19-26

Doi:10.30704/http-www-jivs-net.851210

View : 13 | Download : 6

Publication Date : 2021-04-30

Article Type : Research Paper

Abstract :In this study, the effect of coenzyme Q10 insert ignore into journalissuearticles values(CoQ10); on nitric oxide insert ignore into journalissuearticles values(NO); and total antioxidant insert ignore into journalissuearticles values(TAS); capacity in rats for which experimentally hypothyroidism was induced through PTU was investigated. A total of 32 healthy male Wistar Albino rats weighing 300-350g, approximately 12 weeks old, were used as animal material in the study. . Rats were divided into 4 experimental groups as control insert ignore into journalissuearticles values(K);, Coenzyme Q10 insert ignore into journalissuearticles values(C);, Hypothyroidism insert ignore into journalissuearticles values(H);, and Coenzyme Q10 + Hypothyroidism insert ignore into journalissuearticles values(CH);. During the trial period of three weeks, 3mg CoQ10 insert ignore into journalissuearticles values(10mg/kg/day); was dissolved in 0.3 ml of maize oil and intraperitoneally administered for each animal in group C. In group H, PTU has added to drinking water daily at a weight/volume insert ignore into journalissuearticles values(w/v); ratio of %0.05. In the HC group, coenzyme Q10 was administered intraperitoneally and PTU was administered with drinking water at a rate of %0.05. TT4, TT3, and TSH levels were determined in serum samples and NO and TAS levels in plasma samples. In the present study; the highest plasma NO level among the groups was determined in group H insert ignore into journalissuearticles values(p<0.05); and there was no significant difference between other groups insert ignore into journalissuearticles values(H, C, HC); insert ignore into journalissuearticles values(p>0.05);. The plasma TAS value of group H was found to be significantly higher than the same value in the K, C and HC groups insert ignore into journalissuearticles values(p<0.05);. The plasma TAS level in group C had no difference from the same value in the HC group insert ignore into journalissuearticles values(p>0.05);, although it was higher than the same value of group K insert ignore into journalissuearticles values(p<0.05);. As a result, it was found to cause oxidative stress in hypothyroidism-induced rats with a particular increase in plasma NO levels, and CoQ10 was found to be effective in normalizing the increased plasma NO level due to hypothyroidism.
Keywords : hypothyroidism, coenzyme q10, nitric oxide, total antioxidant capacity, rats