Determination of estrogen receptor, progesterone receptor and epidermal growth factor receptor in canine vaginal tumors and vaginal fold prolapse: A preliminary study

Authors : Zeynep GÜNAY UÇMAK, Atila ATEŞ, Özge ERDOĞAN BAMAÇ, Hazal ÖZTÜRK GÜRGEN, İsmail KIRŞAN, Çağatay TEK, Çağla Nur KÜÇÜKBEKİR, İbrahim KURBAN

Pages : 35-41

Doi:10.30704/http-www-jivs-net.1066060

View : 17 | Download : 7

Publication Date : 2022-04-30

Article Type : Research Paper

Abstract :Eight dogs with a vaginal mass were incorporated into the study. According to the vaginal examination insert ignore into journalissuearticles values(vaginoscopy, exfoliative vaginal cytology); and histopathology, the groups were designed as vaginal fold prolapse insert ignore into journalissuearticles values(Group VFP; n=3); and vaginal tumor insert ignore into journalissuearticles values(Group VT; n=5);. Vaginal tissue samples were homogenized. Tissue homogenates were analyzed with enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA); to determine the levels of estrogen receptor insert ignore into journalissuearticles values(ER);, progesterone receptor insert ignore into journalissuearticles values(PR);, and epidermal growth factor receptor insert ignore into journalissuearticles values(EGFR);. The mean ER level was significantly higher in group VT compared to the group VFP insert ignore into journalissuearticles values(P<0.05);. However, PR and EGFR levels did not showed significance related to the groups insert ignore into journalissuearticles values(P>0.05);. In conclusion, significant differences were obtained between the bitches with VT and VFP related to ER levels although both groups have pathological conditions. Further studies are needed to discuss these pathologies with healthy bitches in terms of steroid receptor and EGFR levels in both vaginal tissue and blood sera.
Keywords : Canine, leiomyoma, leiomyosarcoma, vaginal fold prolapse, receptor