The Value of Cerebrospinal Fluid Polymerase Chain Reaction Test in the Diagnosis of Enteroviral Meningitis in Children

Authors : Ozge METİN, Ayşe KAMAN, Celil UYSAL, Şükrü GÜNER

Pages : 248-252

Doi:10.16899/jcm.756560

View : 13 | Download : 7

Publication Date : 2020-06-25

Article Type : Research Paper

Abstract :Abstract: Background: Non-polio enteroviruses insert ignore into journalissuearticles values(EVs); are emerged as the most common pathogens of aseptic meningitis in children. In this study we aimed to evaluate clinical, laboratory, cerebrospinal fluid insert ignore into journalissuearticles values(CSF); findings and the usefulness of CSF EV polymerase chain reaction on management of pediatric patients diagnosed as EV aseptic meningitis. Material-methods:This study included the pediatric patients with aseptic meningitis between January 2014 and January 2016. Results: A total of 23 patients insert ignore into journalissuearticles values(69.5% boys); diagnosed with EV aseptic meningitis with a median age of 57 months old insert ignore into journalissuearticles values(range; 1-168 months); were included. The most common months of the patients` admission to hospital were July and May. The most common clinical complaints were womiting insert ignore into journalissuearticles values(77.2%);, fever insert ignore into journalissuearticles values(73.9%);, headache insert ignore into journalissuearticles values(59%);, neck stiffness insert ignore into journalissuearticles values(36.3%);, seizure insert ignore into journalissuearticles values(22.7%); and altered consciousness insert ignore into journalissuearticles values(22.7%);. CSF pleocytosis was observed in 16 insert ignore into journalissuearticles values(69.5%); patients and the median CSF white blood cell insert ignore into journalissuearticles values(WBC); count was 50 cells/mm3 ranged from 0 to 500 cells/mm3. It was found that, CSF cell count was significantly increased with age insert ignore into journalissuearticles values(p=0.02);, whereas acute phase reactant levels and CSF biochemical components were statistically similar according to age insert ignore into journalissuearticles values(p>0.05);. Median duration for hospitalization was 6 days insert ignore into journalissuearticles values(range: 1-28 days);. Eight patients insert ignore into journalissuearticles values(34.7%); did not receive any antibiotics. Conclusion: Absence of pleocytosis may be a diagnostic challange in very young infants with aseptic meningitis and CSF cell count significantly increases with age. By using rapid EV-PCR assays in the initial diagnosis of aseptic meningitis, the unnecessary usage of antibiotics in viral meningitis can be reduced and also the duration of hospitalization can be shortened.
Keywords : Aseptic meningitis, children, enteroviruses, polymerase chain reaction