Comparison of Pre-Operative and Post-Operative Thiol-Disulfide Levels in Acute Abdomen Patients

Authors : Altan AYDIN, Hakan BULUŞ, Alper YAVUZ, Mehmet Berksun TUTAN, Murat ALIŞIK, Özcan EREL

Pages : 247-250

Doi:10.16899/jcm.1244258

View : 10 | Download : 7

Publication Date : 2023-03-22

Article Type : Research Paper

Abstract :Aim: To evaluate role of thiol and disulfide homeostasis, a novel marker of oxidative stress, in the follow-up acute abdomen. Material and Method: This prospective study included 107 patients insert ignore into journalissuearticles values(62 men and 45 women); with a diagnosis of acute abdomen insert ignore into journalissuearticles values(AA);. In all patients, age, gender and cause of acute abdomen were recorded. In addition, native thiol insert ignore into journalissuearticles values(-SH);, total thiol insert ignore into journalissuearticles values(tSH); and disulfide insert ignore into journalissuearticles values(-S-S-); levels at baseline, admission and on postoperative day 3 were prospectively recorded and -SS-/-SH, -S-S-/tH and -SH/tSH ratios were calculated. Results: When the causes of acute abdomen were assessed, it was seen that 72 patients insert ignore into journalissuearticles values(67.29%); underwent surgery due to appendicitis while 5 patients insert ignore into journalissuearticles values(4.67%); due to lower GIS perforation, 7 patients insert ignore into journalissuearticles values(6.54%); due to perforated peptic ulcer, 5 patients insert ignore into journalissuearticles values(4.67%); due to sigmoid volvulus, 4 patients insert ignore into journalissuearticles values(3.74%); due to strangulated hernia and 14 patients insert ignore into journalissuearticles values(13.08%); due to miscellaneous reasons. When thiol and disulfide levels were assessed as a single parameter, mean thiol level was 316.71±78.16 insert ignore into journalissuearticles values(327.5); at preoperative period and 264.00±72.85 insert ignore into journalissuearticles values(278.30); at postoperative period. The mean thiol level was significantly decreased at postoperative period insert ignore into journalissuearticles values(p<0.001);. The disulfide//thiol ratio was 5.17±1.56 insert ignore into journalissuearticles values(5.16); at preoperative period and 5.36±2.45 insert ignore into journalissuearticles values(5.28); at postoperative period, indicating no significant difference insert ignore into journalissuearticles values(p=0.563);. Conclusions: In this study, it was found that monitoring these parameters resulting from thiol oxidation are valuable at both preoperative and postoperative period in patients with acute abdomen. Further studies are needed to optimize use of oxidative stress marker together with other established marker.
Keywords : akut karın, disülfid, laboratuvar çalışması, tiyol