THE EVALUATION OF THE EFFECT OF THE TREATMENTS ON OXIDATIVE STRESS AND INFLAMMATION IN PATIENTS RECEIVING DIFFERENT DIALYSIS MODALITIES

Authors : Sümeyra KOYUNCU, Hilal SİPAHİOĞLU, İsmail KOÇYİĞİT, Oktay OYMAK, Bülent TOKGÖZ, Murat SİPAHİOĞLU

Pages : 580-585

Doi:10.16899/jcm.1257359

View : 192 | Download : 153

Publication Date : 2023-07-31

Article Type : Research Paper

Abstract :ABSTRACT Aim: To evaluate the effects of different dialysis methods on oxidative stress and inflammation in patients with end-stage renal disease insert ignore into journalissuearticles values(ESRD); who are newly enrolled in a routine dialysis program. Material and Methods: In this prospective study, 138 ESRD patients and 30 healthy volunteers were evaluated. Fifty-four of 73 hemodialysis insert ignore into journalissuearticles values(HD); patients and 51 of 65 periton dialysis insert ignore into journalissuearticles values(PD); patients completed the study. Other patients were excluded from the study. The levels of superoxide dismutase insert ignore into journalissuearticles values(SOD); and total antioxidant capacity insert ignore into journalissuearticles values(TAC); were measured to determine the oxidative stress status, and IL-6, IL-10, and F2 isoprostane levels were measured to determine the inflammation status, just before the start of dialysis treatment and at 6 months. Results: At the beginning of the study, hs-CRP and IL-6 levels were significantly higher in the patient group compared to the control group insert ignore into journalissuearticles values(p 0.05);, but IL-6 levels were found to be decreased compared to baseline at the 6th month insert ignore into journalissuearticles values(p<0.001);. When HD and PD patient groups were compared with each other, no difference was found between the groups in terms of hs-CRP and IL-10 levels in the 6th month of dialysis treatment. IL-6 levels were found to be significantly higher in the HD group insert ignore into journalissuearticles values(p<0.001);. At the beginning of the study, the F2 isoprostane level was significantly higher in the patient group than the control group insert ignore into journalissuearticles values(p<0.001);, whereas the SOD and TAC levels were significantly lower insert ignore into journalissuearticles values(p=0.001, p=0.024, respectively);. In the HD group, the F2 isoprostane level was found to be significantly higher at 6 months compared to baseline insert ignore into journalissuearticles values(p=0.019);. There was no significant change in SOD and TAC levels. There was no significant difference in F2 isoprostane and TAC levels at 6 months from baseline in the PD group, whereas SOD levels were found to be significantly lower insert ignore into journalissuearticles values(p=0.015);. Conclusion: The oxidative status found in ESRD patients increases with dialysis treatments. Oxidative stress increase is more prominent in HD patients. Therefore, we think that giving antioxidant treatment in patient groups undergoing dialysis treatment may benefit complications related to oxidative stress.
Keywords : hemodiyaliz, periton diyalizi, oksidatif stres