Evaluation of Hematological Biomarkers in Childhood Metabolic Dysfunction Associated Steatotic Liver Disease

Authors : Meltem GÜMÜŞ, Alaaddin YORULMAZ, Hakan CANDAN, Mehmet ÖZTÜRK, Fuat BUĞRUL, Halil Haldun EMİROĞLU

Pages : 1024-1032

Doi:10.16899/jcm.1332759

View : 36 | Download : 48

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Aim:We aimed to investigate the clinical significance and diagnostic value of inflammation-based biomarkers in children with a diagnosis of Metabolic Dysfunction Associated Steatotic Liver Diseaseinsert ignore into journalissuearticles values(MASLD);. Methods:This study was carried out by retrospectively evaluating the files of patients followed up in the Department of Pediatric Hepatology at xxUniversity between July 2022 and January 2023.The study was completed with 120 patients with MASLD diagnosed according to the criteria of the AASLD and EASL, 80 healthy controls.Comparisons were made by calculating laboratory values and formulas through them. Results:There were 50insert ignore into journalissuearticles values(41.7%);girls and 70insert ignore into journalissuearticles values(58.3%);boys in the patient group,and 40 girls insert ignore into journalissuearticles values(50.0%); and 40 boysinsert ignore into journalissuearticles values(50.0%); in the control group.While 80 patients with Grade 0 detected in liver ultrasonography were taken as the control group;102insert ignore into journalissuearticles values(85%); Grade 1 and 18insert ignore into journalissuearticles values(15%);Grade 2-3 patients were considered as the patient group.The values of the patients were compared with the values of healthy volunteers.When the WBC, neutrophil, lymphocyte, platelet, MHR, RPR, RLR, MPR, WMR, GPR, SII and FIB-4score values were compared according to liver grading, a correlation was found in the tests performed on the patients. Conclusion:Our study suggests that the presence of MASLD should be investigated in individuals, and possible complications can be prevented with early diagnosis and treatment approaches.As a result, we think that the use of hematological biomarkers will be useful for the simple and rapid detection of patients with suspected MASLD and who need further examination and treatment.
Keywords : metabolik disfonksiyonla ilişkili steatotik karaciğer hastalığı, çocukluk çağı, biobelirteç, yağlı karaciğer hastalığı