Dynamic thiol/disulphide homeostasis and ischemic modified albumin levels in idiopathic polyhydramnios

Authors : İzzet ÖZGÜRLÜK, Dilek SAHİN

Pages : 845-848

Doi:10.16899/jcm.1346174

View : 34 | Download : 56

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Objective: The aim of study was to determine whether idiopathic polyhydramnios is in relation with dynamic thiol-disulfide homeostasis and ischemia modified albumin levels or not. Materials and methods: In this prospective case- control study, a total of 126 participants were included. The patient group consisted of 56 patients who were diagnosed idiopathic polyhydramnios, and the control group consisted of 56 healthy normal pregnant. Native thiol insert ignore into journalissuearticles values(-SH);, total thiol insert ignore into journalissuearticles values(-SH. -SS);, dynamic disulfide insert ignore into journalissuearticles values(-SS);, values from maternal serum were measured and compared between groups. Results: 112 patients aged between 18-35 years, consisting of 56 idiopathic polyhydramnios and 56 control groups were included in the study. Maternal serum native and total thiol values were significantly higher in study group compared to control group insert ignore into journalissuearticles values(382.2 ±78.5 mmol/L vs. 331.8 ±43.9 mmol/L, p <0.001 and 435.2 ±76.2 mmol/L vs. 368.2 ±47.2 mmol/L, p<0.001);. Disulphide / native thiol ratio and disulphide / total thiol ratio ratio was found to be statistically significantly higher insert ignore into journalissuearticles values(7.3 ±2.2 vs 5.5 ±0.9, p<0.001 and 6.3 ±1.7 vs 5.0 ±0.7, p<0.001);, and native thiol/total thiol ratio ratio was significantly lower insert ignore into journalissuearticles values(87.4 ±3.4 vs 90.1 ±1.4, p<0.001); in control group. Mean cord blood ischemia modified albumin insert ignore into journalissuearticles values(IMA); was 0.69 ±0.02 Absorbance Unit, cord blood native thiol insert ignore into journalissuearticles values(SH); level 410.2 ±80.2, and cord blood total thiol level was 461.1 ±82.1 μmol/l in study group. All parameters except IMA and Native thiol / total thiol ratio were higher in cord blood samples of study group compared to control group. Conclusion: The thiol/disulfide balance shifted towards anti-oxidative status in pregnancies complicated with idiopathic polyhydramnios compared to control group.
Keywords : İMA, tiyol disülfid homeostazı, polihidramnioz