Evaluation of Response to Stereotactic Radiosurgery and Survival Outcomes in Patients with Brain Metastases from Gastrointestinal Cancers

Authors : Ela DELİKGÖZ SOYKUT, Eylem ODABASİ, Serdar ŞENOL, Salih Buğra YILMAZ, Hatice TATAROĞLU, Ahmet BARAN

Pages : 939-948

Doi:10.16899/jcm.1351577

View : 20 | Download : 30

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Aim: Gastrointestinal cancers rarely metastasize to the brain and constitute 4-8% of all brain metastases insert ignore into journalissuearticles values(BM);. Survival is generally poor for BM from gastrointestinal cancers and stereotactic radiosurgery insert ignore into journalissuearticles values(SRS); is frequently used in its management. Since the data are still insufficient due to their rare presentation, we aim to analyze the clinical results of patients who underwent SRS for BM due to gastrointestinal cancers. Material and Method: We retrospectively reviewed patients with BM from gastrointestinal cancers who received robotic SRS with CyberKnife at our institute from October 2013 to December 2022. Clinical characteristics and treatment outcomes were recorded. Study endpoints were local control rates, distant brain control rates, and overall survival insert ignore into journalissuearticles values(OS);. Results: A total of 61 BM were detected in 42 patients. The median clinical follow-up time was 7 insert ignore into journalissuearticles values(0.5-36); months. Nine lesions progressed in the irradiated area, 14 new lesions were observed outside the irradiated area. The local control rate was 85.1% and the distant brain control rate was 77%. The median OS was 8 months; 12-month and 24-month OS were 31.6% and 10.5%, respectively. Patients with high performance status had better OS insert ignore into journalissuearticles values(p=0.016);. The prognostic scoring scales RPA and GI-GPA were both associated with OS insert ignore into journalissuearticles values(p=0.049, p=0.002);. Multivariate analysis found a significant association between GI-GPA classes and OS insert ignore into journalissuearticles values(p=0.011);. Conclusion: We obtained comparable results in terms of local control, distant brain control and OS in this challenging patient population. The use of GI-GPA prognostic scoring scales in routine practice will guide the selection of the most appropriate patient for SRS.
Keywords : Beyin Metastazı, Gastrointestinal Kanser, Prognoz, Stereotaktik Radyocerrahi