Liver Protection of Hydroxytyrosol Mediated by Spexin and TRPM2

Authors : Elif ONAT, Nevin KOCAMAN

Pages : 954-958

Doi:10.16899/jcm.1352503

View : 39 | Download : 51

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Background/Aim: In the study, the role of Spexin insert ignore into journalissuearticles values(SPX); and TRPM2 in the protective effect of Hydroxytyrosol insert ignore into journalissuearticles values(HT); in rats given Corn Syrup was evaluated. Material and Method: The rats were divided into 4 groups insert ignore into journalissuearticles values(6 rats in each); insert ignore into journalissuearticles values(Control, HT, Corn Syrup, Corn Syrup +HT);. Rats were given 30% Corn Syrup with drinking water for 6 weeks. 4 ml/kg/day liquid containing HT was applied by oral gavage alone and together with Corn Syrup for 6 weeks. Molecular parameters SPX and TRPM2 were examined histopathologically in liver tissue. Results: The SPX levels decreased and the TRPM2 levels increased more in the Corn Syrup given Group than the Control Group. SPX levels increased and TRPM2 levels decreased after HT treatment. In the HT Group only, no differences were detected when compared to the control Group. Conclusion: SPX and TRPM2 may mediate the protective effect of HT on the liver in rats given corn syrup.
Keywords : Mısır Şurubu, Hidroksitirosol, Spexin, TRPM2