Paraoxonase-1 and Arylesterase Activities in Children with Acute Bronchiolitis

Authors : Fatih Akin, Abdullah Yazar, Esra Türe, Ümit Gültekin, Ahmet Osman Kiliç, Cemile Topçu, Dursun Odabaş, Alaaddin Yorulmaz

Pages : 1064-1070

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Publication Date : 2023-11-30

Article Type : Research Paper

Abstract :Abstract Aim: Acute bronchiolitis is a disease frequently seen in children under two years of age. The paraoxonase 1 (PON1) enzyme functions as an antioxidant. Arylesterase (ARES) is accepted as the indicator of the main protein. The aim of this study is to investigate whether PON1 and ARES activity levels can be used as an indicator of the disease in children with acute Materials and Methods: Ninety one patients with acute bronchiolitis who atmitted to pediatric emergency unit and 39 age- and sex-matched healthy children were included in the study. Patients were divided into 3 groups as mild, moderate and severe bronchiolitis according to Wang scoring system. Results: The mean serum PON1 activity levels of all patients with bronchiolitis were 188.05 ± 101.94 U/L, and the mean of the control group was 302.87 ± 170.52 U/L. The mean serum ARES activity levels of all patients with bronchiolitis were 408.44 ± 109.95 kU/L, and the mean of the control group was 785.45 ± 168.45 kU/L. Mean serum PON1 and ARES activity levels were found to be statistically significantly lower in patients with acute bronchiolitis. No statistically significant difference was found among groups according to disease severity. Conclusion: We found that PON1 and ARES activity levels were lower in patients with acute bronchiolitis than in controls. The results of our study show that low PON 1 and ARES activity levels may play a role in the pathogenesis of acute bronchiolitis and that oxidative stress may have an effect on the development of bronchiolitis.
Keywords : akut bronşiolit, arilesteraz ARES, çocuk, oksidatif stress, paraoxonaz 1 PON1