Gastroprotective Effects of Jujuba (Ziziphus jujuba) Fruit Extract Against the Ethanol-Related Gastric Ulcer in Rats

Authors : Ayhan Tanyeli, Mustafa Can Güler, Ersen Eraslan, Mehmet Ramazan Bozhüyük, Fazile Nur Ekinci Akdemir, Erdem Toktay, Nezahat Kurt, Gülay Özkan, Esra Çapanoğlu Güven

Pages : 1046-1052

View : 82 | Download : 107

Publication Date : 2023-11-30

Article Type : Research Paper

Abstract :Abstract Objective: Gastric ulcer is a global health problem. Alcohol consumption and nonsteroidal anti-inflammatory drugs may lead to gastric ulcers. Here, we examined the possible gastroprotective effects of Ziziphus jujuba (Zj) fruit extract on a rat model of ethanol-induced gastric ulcer. Material and Methods: Chemical properties of Zj were specified using performance liquid chromatography coupled to mass spectrometry. The animals were administered Zj extract (4-8 ml/kg) before administering absolute ethanol. Oxidative stress and proinflammatory markers, immunoexpression of NF-ĸB and caspase-3 were measured to evaluate Zj’s effects. Results: Zj fruit extract significantly reduced values of cytokines such as TNF-α, IL-1β, and IL-6 and the expressions of NF-ĸB and caspase-3 in the immunohistologic analysis. We found out ulcerative foci in the ulcer group in the histopathological analysis, while we didn’t observe ulcerative foci in the treatment groups. Conclusion: This experimental study showed that Zj fruit ameliorated the ethanol-induced gastric ulcer model in rats.
Keywords : Etanol, gastrik ülser, proinflamatuar sitokinler, kaspaz 3, Ziziphus jujuba