Evaluation of factors affecting 90-day mortality in patients hospitalized due to pulmonary thromboembolism

Authors : Derya HOŞGÜN, Semih AYDEMİR, Can ATEŞ

Pages : 543-551

Doi:10.32322/jhsm.925332

View : 24 | Download : 7

Publication Date : 2021-09-05

Article Type : Research Paper

Abstract :Background: Pulmonary thromboembolism insert ignore into journalissuearticles values(PTE); is a leading cause of death from vascular events. In the pathophysiology of PTE, inflammatory mediators have been shown to be upregulated and to interact with coagulation factors.In this study, we aimed to investigate the role of symptoms, clinical and radiological findings, and the blood parameters measured at presentation within the first 24 h after the onset of the symptoms in predicting 90-day mortality and intensive care unit insert ignore into journalissuearticles values(ICU); requirement in patients with PTE. Methods: The retrospective study included 264 PTE patients that were followed up at our Chest Diseases clinic and ICU between 2014 and 2019. Results: The 264 patients comprised 55.3% women and 44.7% men with a mean age of 62.80±15.95 years. Of these, 189 of them were hospitalized in the Chest Diseases clinic and the remaining 75 patients were followed up at ICU. Total mortality occurred in 8 insert ignore into journalissuearticles values(3%); out of 264 patients. Risk factors for 90-mortality included white blood cell count insert ignore into journalissuearticles values(WBC);, red blood cell distribution width insert ignore into journalissuearticles values(RDW);, mean platelet volume insert ignore into journalissuearticles values(MPV);/RDW ratio, right ventricular dilatation insert ignore into journalissuearticles values(RVD);, recombinant tissue plasminogen activator insert ignore into journalissuearticles values(rtPA); therapy, ICU hospitalization, and increased APACHE II insert ignore into journalissuearticles values(Acute Physiology and Chronic Health Evaluation II); scores insert ignore into journalissuearticles values(p<0.05);. Conclusion: The results indicated that TTE findings, baseline hemodynamic parameters and symptoms, rtPA therapy, and CBC parameters including WBC, NE, and RDW are significant risk factors for predicting both mortality and ICU requirement.
Keywords : Pulmonary embolism, Mortality, İnflammatory