The predictive value of systemic immune inflammation index on long-term outcomes among acute pulmonary embolism patients

Authors : Altuğ ÖSKEN, Neşe ÇAM

Pages : 557-563

Doi:10.32322/jhsm.931405

View : 27 | Download : 14

Publication Date : 2021-09-05

Article Type : Research Paper

Abstract :Aim: Systemic immune-inflammation index insert ignore into journalissuearticles values(SII); is a novel marker that predicts adverse clinical outcomes among patients with malignancy and cardiovascular diseases. In the present study, we hypothesized that SII could provide more additional information in the prediction of long-term mortality among patients with acute pulmonary embolism insert ignore into journalissuearticles values(APE);. Methods: Consecutive patients insert ignore into journalissuearticles values(n=514); who were followed up and treated with a diagnosis of APE were included in the study. The study group was divided into those survivors and non-survivors. Demographic, clinical, laboratory, and echocardiographic characteristics were compared between groups. Results: A total of 28 insert ignore into journalissuearticles values(5.4%); patients died in the 30 days. Besides, during a follow-up period of 29 [12-53] months, 52 patients insert ignore into journalissuearticles values(10.1%); died. In the Cox-regression analysis, age [odds ratio insert ignore into journalissuearticles values(OR);: 1.052, 95% confidence interval insert ignore into journalissuearticles values(CI);: 1.034–1.071; p < 0.01], right ventricle end-diastolic diameter basal insert ignore into journalissuearticles values(OR: 3.227, 95% CI: 1.902–5.474; p < 0.001);, left ventricular ejection fraction insert ignore into journalissuearticles values(OR: 0.968, 95% CI: 0.948–0.988); and SII index insert ignore into journalissuearticles values(OR: 2.129, 95% CI: 1.290–3.515); were the independent predictors of overall mortality among the study population. In the receiver operator characteristic curve analysis, the area under the curve values of the SII index for overall mortality was 0.703 insert ignore into journalissuearticles values(95% CI: 0.629–0.777);. SII with an optimal cutoff value of 1111 × 109 predicted the overall mortality with a sensitivity of 72% and specificity of 51%. Conclusion: The SII index, an inexpensive and easily calculable parameter, was a strong predictor of overall mortality in patients with APE.
Keywords : Acute pulmonary embolism, risk stratification, systemic immune inflammation index