The association between urine pH and abnormal glucose tolerance in adults

Authors : Hasan SÖZEL, Fatih YILMAZ

Pages : 589-597

Doi:10.32322/jhsm.941655

View : 16 | Download : 15

Publication Date : 2021-09-05

Article Type : Research Paper

Abstract :Aim: Urine Ph insert ignore into journalissuearticles values(U-pH); is a clinical indicator of acid excretion in the urine and acid load in the diet. The association between low U-pH and net acid secretion with obesity, metabolic syndrome, diabetes, chronic kidney disease, and uric acid nephrolithiasis were showed. The aim of this study is to evaluate the U-pH in patients with different glucose tolerance status. Materials and methods: This study was designed as single-center, retrospective, and cross-sectional. A total of 1666 subjects insert ignore into journalissuearticles values(male/female: 531/1135); were divided into three groups according to their OGTT results: group 1 = normal glucose tolerance insert ignore into journalissuearticles values(NGT);, group 2 = prediabetes, group 3 = T2DM. Than subjects were divided into five groups according to their OGTT results: group 1 = NGT, group 2 = impaired fasting glucose insert ignore into journalissuearticles values(IFG);, group 3 = isolated impaired glucose tolerance insert ignore into journalissuearticles values(IGT);, group 4 = both IFG and IGT, and group 5 = T2DM. Additionally, patients were divided into three groups according to their glycated hemoglobin insert ignore into journalissuearticles values(HbA1c); results: group 1 = NGT, group 2 = prediabetes, and group 3 = T2DM. U-pH values and other outcomes were compared between groups. Results: Age, male gender, hemoglobin, creatinine, triglycerides, and OGTT groups showed significant association with low U-pH through univariate logistic regression analyses. In model 1 insert ignore into journalissuearticles values(with OGTT 3 groups);, it was found that creatinine insert ignore into journalissuearticles values(OR: 3.471; % 95 CI: 1.377-8.749; p=0.008); and triglycerides insert ignore into journalissuearticles values(OR: 1.001; %95 CI: 1-1.003; p = 0.013); were positively associated with low U-pH. Patients with DM insert ignore into journalissuearticles values(OR:1.437; %95 CI: 1.015-2.035; p=0.041); had higher risk for low U-pH compared to patients with NGT. In Model 2 insert ignore into journalissuearticles values(with OGTT 5 groups);, creatinine insert ignore into journalissuearticles values(OR:3.423; %95 CI: 1.354-8.654; p = 0.009); and triglycerides insert ignore into journalissuearticles values(OR:1.001; %95 CI: 1-1.003; p = 0.014); were identified as independent predictive factors associated with low U-pH. Patients with IFG+IGT insert ignore into journalissuearticles values(OR:1.522; %95 CI: 1.083-2.138; p=0.015); and DM insert ignore into journalissuearticles values(OR:1.447; %95 CI: 1.022-2.049; p=0.037); had higher risk for low U-pH compared to patients with NGT. Conclusion: In this study, the frequency of diabetes was found to be increased in patients with low U-pH. More detailed clinical studies are needed to evaluate the relationship between total acid load in the body and U-pH and glucose tolerance disorders.
Keywords : Urine pH, Prediabetes, Diabetes Mellitus