Is macrocytic erythrocyte a new prognostic parameter in critical COVID-19 disease?

Authors : Veysel Garani SOYLU, Sedat GÜLTEN, Ayşe YILMAZ, Öztürk TAŞKIN, Ufuk DEMİR, Funda ÇATAN İNAN

Pages : 828-834

Doi:10.32322/jhsm.971934

View : 20 | Download : 5

Publication Date : 2021-09-24

Article Type : Research Paper

Abstract :Introduction: In critical COVID- 19 patients, we aimed to examine the relationship mortality between the parameters and the macrocytic/microcytic erythrocyte population that are routinely evaluated in each patient admitted to the intensive care unit. Material and Method: It is a retrospective cross-sectional study and was conducted in Kastamonu University, Faculty of Medicine, a tertiary hospital intensive care units located in the North of Turkey .198 nonanemic critical COVID-19 patients treated between November 2020 and February 2021 were evaluated. The patients were divided into two groups as survival and non survival. Apache II score, saps II score and routine blood examinations of the patients were evaluated. Results: Among the groups; APACHE II score insert ignore into journalissuearticles values(p<0.001);, SAPS II score insert ignore into journalissuearticles values(p<0.001);, CRP insert ignore into journalissuearticles values(p<0.001);, ferritin insert ignore into journalissuearticles values(p<0.001);, d-dimer insert ignore into journalissuearticles values(p<0.001);, platelet distribution width insert ignore into journalissuearticles values(p<0.009);, mean platelet volume insert ignore into journalissuearticles values(p=0.005); and large platelet ratio insert ignore into journalissuearticles values(p=0.02); values ​​were higher, platelet counts insert ignore into journalissuearticles values(p=0.02); were lower, and these parameters were statistically significant between the two groups. There was no difference in erythrocyte distribution volume and microcytic erythrocyte percentage between the groups, but according to the cox regression analysis, each unit increase in macrocytic erythrocyte percentage was associated with a 1.203-fold increase in mortality. Conclusion: Routine procedures performed in every patient admitted to the intensive care unit can provide information about mortality. Macrocytic erythrocyte percentage, which is not generally considered in non-anemic patients, may be a new marker for mortality.
Keywords : Macrocytic Erythrocyte Population, Intensive Care Unit, Covid 19, Complete Blood Count, Mortality