Real-life data of patients with hypoparathyroidism: a case-control study

Authors : Vedat TAN, Alparslan Kemal TUZCU, Zafer PEKKOLAY

Pages : 45-48

Doi:10.32322/jhsm.993320

View : 16 | Download : 9

Publication Date : 2022-01-17

Article Type : Research Paper

Abstract :Objective: This study aims to investigate real-life data of patients with hypoparathyroidism. Material and Method: This retrospective case-control study was carried out in a tertiary endocrine center between 1 January 2010 and 31 December 2019. Patients with a confirmed diagnosis of persistent hypoparathyroidism and healthy controls were included. Demographic characteristics of the patients, laboratory findings, etiologies of hypoparathyroidism, treatments they received, reasons for hospitalization, and complications were investigated. Results: Sixty-five patients insert ignore into journalissuearticles values(mean age 42.80±13.4 years, 91% female); with hypoparathyroidism, and 54 healthy controls insert ignore into journalissuearticles values(mean age 33.58±11.9 years, 65% female); were included. Mean calcium level 7.95±0.92 mg/dl, and mean PTH level 9.99±6.30 pg/ml in hypoparathyroidism. Regarding the etiology of HypoPT, 51 insert ignore into journalissuearticles values(78%); patients had hypoPT due to surgery; 14 insert ignore into journalissuearticles values(22%); patients developed HypoPT due to non-surgical causes. In patients with hypoPT who underwent surgery, the mean calcium value was 8.03±0.93 mg/dl; the mean calcium value in patients with non-surgical HypoPT was 7.67±0.85 mg/dl. The mean PTH levels in non-surgical group, other group 10.16±6.21 pg/ml and 9.36±6.82 pg/ml, respectively. The most common surgery was due to multinodular goiter insert ignore into journalissuearticles values(72%);. In 46 percent, the most common treatment was calcitriol 0.5 mcg/day and calcium 2000 mg/day. Nearly half of the patients had treatment non-compliance insert ignore into journalissuearticles values(46%);. Eighteen percent of patients had kidney stones. Forty-three percent of the patients had been hospitalized in the last year. The most common reason for the hospitalization of patients with hypoparathyroidism was hypocalcemia, and the most common reason for this was treatment non-compliance. Conclusion: In our study, the most common cause of hypoparathyroidism is surgery due to multinodular goiter. The most common reason for hospitalization is treatment non-compliance. Up to one-fifth of patients had kidney stones.
Keywords : Hypoparathyroidism, real life data, hypocalcemia