Morphological and immunohistochemical evaluation of interface lesions between chronic lymphocytic thyroiditis and papillary thyroid cancers

Authors : Pınar CELEPLİ, İrem BİGAT, Salih CELEPLİ, Sema HÜCÜMENOĞLU

Pages : 552-557

Doi:10.32322/jhsm.1052732

View : 18 | Download : 7

Publication Date : 2022-03-15

Article Type : Research Paper

Abstract :Objective: To evaluate the expression of papillary thyroid carcinoma-associated tumor markers in reactive and dysplastic changes showing papillary thyroid carcinoma-like nuclear features in chronic lymphocytic thyroiditis cases. Material and Method: In this study, we retrospectively analyzed 84 cases diagnosed with chronic lymphocytic thyroiditis based on the analysis of thyroidectomy specimens in our center over the last five years. We classified them as normal, reactive and dysplastic changes and performed an immunohistochemical analysis using HBME-1, Galectin-3, Cytokeratin 19, and Cyclin D1. Results: The mean age of the patients was 45.5 years, and 68 were female and 16 were male. According to the morphological features, 42.9% of the were classified to have normal morphology, 44.0% reactive atypia, and 13.1% follicular epithelial dysplasia insert ignore into journalissuearticles values(FED);. Of the chronic lymphocytic thyroiditis cases, 42.9% were associated with malignancy, with the most common accompanying malignancy being papillary thyroid cancer insert ignore into journalissuearticles values(36.9%);. Immunohistochemically: for HBME-1, FED insert ignore into journalissuearticles values(72.7%); was higher insert ignore into journalissuearticles values(p<0.05); than normal and reactive atypia insert ignore into journalissuearticles values(0.0%);; for Galectin-3, FED insert ignore into journalissuearticles values(63.6%); was higher insert ignore into journalissuearticles values(p<0.05); than normal and reactive atypia insert ignore into journalissuearticles values(0.0%);; for Cytokeratin 19, Reactive atypia insert ignore into journalissuearticles values(75.7%); and FED insert ignore into journalissuearticles values(90.9%); were higher than normal insert ignore into journalissuearticles values(44.4%);; and for Cyclin-D1, Reactive atypia insert ignore into journalissuearticles values(62.2%); and FED insert ignore into journalissuearticles values(81.8%); were higher than normal insert ignore into journalissuearticles values(33.3%);. Conclusions: We consider that reactive and dysplastic changes including papillary thyroid carcinoma-like nuclear changes may support preneoplastic changes in terms of morphology and immunoprofile in chronic lymphocytic thyroiditis cases.
Keywords : Thyroid cancer, follicular epithelial dysplasia, chronic lymphocytic thyroiditis