Platelet-lymphocyte ratio predicts poor prognosis in stage II/III colon and rectum cancer

Authors : Suat BENEK, Şevki PEDÜK, Mehmet ZENGIN

Pages : 491-498

Doi:10.32322/jhsm.1056614

View : 16 | Download : 10

Publication Date : 2022-03-15

Article Type : Research Paper

Abstract :Objective: There is an increasing number of studies in the literature reporting that serum platelet/lymphocyte ratio insert ignore into journalissuearticles values(PLR); can provide useful prognostic data for various cancers. In the present study, the effects of platelet-lymphocyte ratio on survival in stage II/III colorectal cancers insert ignore into journalissuearticles values(CRC); were examined. Material and Method:A total of 106 Stage II/III CRC patients who underwent curative surgery 2015-2020 were included in the study. Emergency cases and patients diagnosed with other than adenocarcinoma were excluded from the study. The demographic data of the patients, preoperative imaging and laboratory results, postoperative pathology reports, and patient follow-up examination data were obtained from hospital records. The relations between demographic, histopathological, hematological values ​​and the prognosis was analyzed in terms of statistical significance. Results:Among the 106 patients, 62 insert ignore into journalissuearticles values(58.5%); were male and 44 insert ignore into journalissuearticles values(41.5%); were female. The mean age was 64.3±12.01 insert ignore into journalissuearticles values(23-89);. The mean follow-up period was calculated as 24.6±15.8 insert ignore into journalissuearticles values(2-63); months. When the pathology reports were reviewed, it was found that the mean tumor diameter was 5.3±2.33 cm insert ignore into journalissuearticles values(2-17); and the mean metastatic lymph node was 1.8±2.4 insert ignore into journalissuearticles values(0-10);. The PLR ratio was determined as a poor prognostic factor affecting survival in the cox regression analysis, in which preoperative complete blood count, c-reactive protein and albumin values, neutrophil-lymphocyte ratio insert ignore into journalissuearticles values(NLR);, lymphocyte-monocyte ratio insert ignore into journalissuearticles values(LMR);, and PLR were compared, and was separated from other variables insert ignore into journalissuearticles values(P=0.002 CI= 95%);. When variables such as age, clinical stage, and tumor diameter were included in the model, PLR was similarly found to be an important predictive variable insert ignore into journalissuearticles values(P= 0.002);. When only NLR, LMR, and PLR were evaluated, PLR again came to the forefront with a significance value of P=0.01. Also, high neutrophil count, increased platelet distribution volume insert ignore into journalissuearticles values(PDW);, advanced age, and perineural invasion insert ignore into journalissuearticles values(PNI); were found to be significant factors in predicting poor prognosis. Conclusions: High PLR is a poor prognostic factor for CRC patients. For this reason, it may be necessary to follow a more aggressive strategy in the management of postoperative treatment in patients who have high PLR.
Keywords : Platelet Lymphocyte Ratio, adjuvant chemotherapy, colorectal cancer, Stage II III, prognostic factor