The relationship between vitamin D deficiency and hypertensive organ damage

Authors : Cengiz ŞABANOĞLU, İbrahim Halil İNANÇ

Pages : 1704-1712

Doi:10.32322/jhsm.1173794

View : 17 | Download : 8

Publication Date : 2022-10-25

Article Type : Research Paper

Abstract :Aim: In this study, we aimed to examine the relationship between vitamin D level and target organ damage insert ignore into journalissuearticles values(TOD); in primary hypertension patients by eliminating the effects of hypertension duration and antihypertensive treatments. Material and Method: The study included 144 patients with primary hypertension. Vitamin D levels were classified as sufficiency insert ignore into journalissuearticles values(VDS);, deficiency insert ignore into journalissuearticles values(VDD);, and severe deficiency insert ignore into journalissuearticles values(VDSD);. In case of more than one TOD indicator insert ignore into journalissuearticles values(microalbuminuria or proteinuria, left ventricular mass index and carotid intima-media thickness);, it was considered as multi organ involvement insert ignore into journalissuearticles values(OI);. In the multiple regression model, besides the traditional risk factors, the effects of hypertension duration and anti-hypertensive treatments were adjusted. Results: The rates of VDS and VDD were lower in TOD insert ignore into journalissuearticles values(+); compared to TOD insert ignore into journalissuearticles values(-); insert ignore into journalissuearticles values(14.1% vs 51.5%, 32.1% vs 42.4%; p<0.001);, while VDSD ratio was higher insert ignore into journalissuearticles values(53.8% vs 6.1%, p<0.001);. VDSD ratio was higher in hypertensive patients with single-OI compared to TOD insert ignore into journalissuearticles values(-);, while its was higher in patients with multi-OI compared to single-IO. In the multivariable regression model; showed that 1 ng/mL decrease in the Vitamin D increased the probability of TOD by 1.22 folds [vs TOD insert ignore into journalissuearticles values(-);], probability of single organ involvement by 1.19 folds [vs TOD insert ignore into journalissuearticles values(-);], and probability of multi-IO by 1.11 folds insert ignore into journalissuearticles values(vs single-IO);. Conclusion: In hypertensive patients, a decrease in vitamin D levels is associated with an increase in TOD indicators. The risk of developing TOD and multi-IO is higher in vitamin D deficiency. Vitamin D supplements may be beneficial in hypertensive organ damage, regardless of disease duration and anti-hypertensive treatments.
Keywords : Atherosclerosis, hypertension, vitamin D, target organ damage