FeNO, systemic inflammation and other risk factors for osteoporosis in COPD

Authors : Ömür GÜNGÖR, A. Füsun KALPAKLIOĞLU

Pages : 122-127

Doi:10.32322/jhsm.1212043

View : 16 | Download : 9

Publication Date : 2023-01-12

Article Type : Research Paper

Abstract :Aim: The bone is one of the tissues that is adversely affected as a result of inflammation in COPD. The aim of this study is to examine the relationship between airway inflammation, systemic inflammation and osteoporosis in COPD. Material and Method: A cross-sectional study was performed, including 50 patients with stable COPD. FeNO as a marker of airway inflammation; hs-CRP, WBC and fibrinogen as systemic inflammation markers; arterial blood gas, BMI and FEV1 were measured. To identify osteoporosis, DEXA was performed. Results: The prevalence of osteoporosis was 26%. Osteoporosis was associated with WBC and hs-CRP insert ignore into journalissuearticles values(OR: 1.80, 95% CI, 1.26-2.57 and OR: 2.32, 95% CI, 1.28-4.20, respectively);. It was observed that the risk increased as FEV1 and BMI decreased insert ignore into journalissuearticles values(OR: 0.94, 95% CI, 0.89-0.98 and OR: 0.75, 95% CI, 0.61-0.91, respectively);. There was no relationship between osteoporosis and FeNO and fibrinogen insert ignore into journalissuearticles values(OR: 1.05, 95% CI, 0.99-1.12 and OR: 1.04, 95% CI 0.98-1.09, respectively);. Arterial blood gases insert ignore into journalissuearticles values(PaO2 and PaCO2); were not effective on osteoporosis insert ignore into journalissuearticles values(OR: 1.01, 95% CI, 0.95-1.05 and OR: 1.04, 95% CI, 0.90-1.19, respectively);. The cut-off values of hs-CRP and WBC for osteoporosis risk were 15.9 mg/L and 11.6 ×10⁹/L, respectively. Conclusions: Osteoporosis was associated with low BMI, airway stenosis and high levels of hs-CRP and WBC.
Keywords : COPD, inflammation, osteoporosis, FeNO, arterial blood gas