Distribution of ABO blood groups and Rh factor in benign and malign thyroid nodules

Authors : Muzaffer Serdar DENİZ

Pages : 462-466

Doi:10.32322/jhsm.1243805

View : 21 | Download : 5

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: Many factors affect the diagnostic value of the fine-needle aspiration biopsy applied for these thyroid nodules. I aimed to investigate whether one of these factors would be ABO blood groups and Rh factor and examine the relationship of these factors with the Bethesda categorization. Additionally, I aimed to evaluate ABO blood groups and Rh factors in patients with thyroid cancer. Material and Method: This study was planned in a cross-sectional retrospective design. The data of the patients were obtained from the hospital data bank. In the analysis of 801 patients following the acceptance criteria, 412 patient data were obtained. Patients were divided into 4 insert ignore into journalissuearticles values(O, A, B, and AB groups); according to their blood groups and analyzed for nodules insert ignore into journalissuearticles values(solitary/ multinodular);. Nodules were divided into malignant and benign, according to histopathological diagnosis, and all were analyzed. Results: There was no difference in analyzing the demographic data according to the blood groups. The rates of the FNAB history were 51 insert ignore into journalissuearticles values(32.3%);, 39 insert ignore into journalissuearticles values(24.2%);, 14 insert ignore into journalissuearticles values(26.4%);, and 13 insert ignore into journalissuearticles values(32.5%); in the same order of blood groups insert ignore into journalissuearticles values(p=0.393);. In the analysis of the nodule type, multinodular did not differ from solitary nodules among the blood groups [O: 141 insert ignore into journalissuearticles values(89.2%);; A:140insert ignore into journalissuearticles values(87%);, B: 46insert ignore into journalissuearticles values(86.8%);, and AB: 35insert ignore into journalissuearticles values(87.5%);]. Thyroid function status insert ignore into journalissuearticles values(euthyroid, hypothyroid, or hyperthyroid); was similar for all the blood groups insert ignore into journalissuearticles values(p=0.815);. The O-group had 1 insert ignore into journalissuearticles values(0.6%); patient with Bethesda score-6, and the A-group had 2 insert ignore into journalissuearticles values(1.2%); patients with Bethesda score-6. For Bethesda score-5, per blood group had 2 patients. The histopathological distribution of malign nodules insert ignore into journalissuearticles values(p=0.782); is as follows: O-groups: 6 insert ignore into journalissuearticles values(33.3%); insert ignore into journalissuearticles values(Rh+:27%; Rh-:5,5%);, A groups: 7insert ignore into journalissuearticles values(63,6%); insert ignore into journalissuearticles values(Rh+:54,5%; Rh-:0,9%);, B groups: 2insert ignore into journalissuearticles values(20%);insert ignore into journalissuearticles values(Rh+:20%; Rh-:0%); and AB groups: 1insert ignore into journalissuearticles values(33%); insert ignore into journalissuearticles values(Rh+:33%); Rh-:0%);. Conclusion: Malign nodule rate was highest in the A-group and lowest in the B groups, although it did not differ in the overall analysis. No relationship was found between the Bethesda categorization of nodules, their sizes, type of nodules, type of thyroid cancer, and ABO blood groups.
Keywords : Thyroid biopsy, Bethesda score, ABO blood group, malign nodule, benign nodule