The relationship between levels of apolipoprotein A1 and B in aqueous and serum with stage of diabetic retinopathy

Authors : İnci Elif ERBAHÇECİ TİMUR, Kemal ÖRNEK, Osman ÇAĞLAYAN

Pages : 546-551

Doi:10.32322/jhsm.1253299

View : 15 | Download : 6

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: To determine the association between serum and aqueous apolipoprotein insert ignore into journalissuearticles values(Apo); A1 and Apo B levels and Apo B/A1 ratio in diabetic retinopathy. Material and Method: This cross-sectional prospective study included 63 diabetic patients with or without retinopathy and 38 control subjects who underwent cataract surgery. The study groups were as follows; healthy subjects insert ignore into journalissuearticles values(Group 1);, diabetic patients without retinopathy insert ignore into journalissuearticles values(Group 2);, with non-proliferative diabetic retinopathy insert ignore into journalissuearticles values(Group 3);, and with proliferative diabetic retinopathy insert ignore into journalissuearticles values(Group 4);. Serum and aqueous Apo A1 and Apo B levels were determined by using an enzyme-linked immunosorbent assay. Results: The amount of Apo B was determined in aqueous samples of all insert ignore into journalissuearticles values(100%); patients in Group 4 and 77.7% of patients in Group 3.The mean serum Apo B/A1 ratio was significantly higher in Group 2, Group 3 and Group 4 compared with Group 1 insert ignore into journalissuearticles values(p=0.002, p=0.037 and p<0.001, respectively);. The aqueous Apo B level, aqueous and serum Apo B/A1 levels were significantly correlated with the severity of retinopathy in diabetic patients insert ignore into journalissuearticles values(all p<0.001);. Conclusion: Higher serum and aqueous Apo B/A1 ratio were significantly associated with the stage of diabetic retinopathy.
Keywords : Aqueous, serum, apolipoprotein A1, apolipoprotein B, diabetes, diabetic retinopathy