Relation of parathyroid hormone with malnutrition in peritoneal dialysis patients

Authors : Emel TALI, Rumeyza KAZANCIOGLU

Pages : 800-804

Doi:10.32322/jhsm.1282948

View : 60 | Download : 82

Publication Date : 2023-07-30

Article Type : Research Paper

Abstract :Aims: Protein-energy wasting syndrome is a risk factor specific to ESRD is protein-energy wasting insert ignore into journalissuearticles values(PEW); syndrome. Clinical and experimental studies have suggested that secondary hyperparathyroidism plays a vital role in increasing energy expenditure in patients with ESRD. The geriatric nutritional risk index insert ignore into journalissuearticles values(GNRI); is used to evaluate nutritional status in various pathological conditions. Considering the effect of parathormone on malnutrition and studies indicating that parathyroid hormone causes weight loss, we aimed to investigate the relationship between malnutrition and parathyroid hormone insert ignore into journalissuearticles values(PTH); in our patients using GNRI. Methods: Forty-nine patients without known malignancy, liver disease, or chronic inflammatory disease who underwent peritoneal dialysis were included in the study. Patient data were recorded from these files. Height and weight were measured. GNRI was calculated by the formula 14.89 × serum albumin insert ignore into journalissuearticles values(g/dL); + [41.7 × bodyweight/ideal body weight Results: Forty-nine patients insert ignore into journalissuearticles values(29 females, 59.2%); were included in the study. Three insert ignore into journalissuearticles values(6.1%);, seven insert ignore into journalissuearticles values(14.3%);, and seven insert ignore into journalissuearticles values(14.3%); patients had severe, moderate, and mild malnutrition, respectively. GNRI was positively correlated with albumin, hematocrit, and calcium levels insert ignore into journalissuearticles values(r=0.757, r=0.355, r=0.423; p<0.05, respectively);. GNRI was negatively correlated with dialysis vintage insert ignore into journalissuearticles values(r=-0.303, p=0.038); and PTH insert ignore into journalissuearticles values(r=-0.287; p=0.046);. Conclusion: This study demonstrated a relationship between malnutrition and hyperparathyroidism. Increased PTH levels may cause phenotypic switching from white to brown fat via PTH receptors.
Keywords : Peritoneal dialysis, protein energy malnutrition, secondary hyperparathyroidism