The impact of COVID-19 on patients with Parkinson disease

Authors : Esma KOBAK TUR, Buse Çağla ARI

Pages : 815-820

Doi:10.32322/jhsm.1306662

View : 97 | Download : 88

Publication Date : 2023-07-30

Article Type : Research Paper

Abstract :Aims: Viral infections have been implicated in the development of Parkinson disease insert ignore into journalissuearticles values(PD);. It has been observed that the presence of SARS-CoV-2 in dopaminergic cells can expedite the degeneration process and potentially exacerbate symptoms. The objective of this study was to assess the impact of the COVID-19 pandemic on individuals with PD. Methods: A total of 60 patients were enrolled in the study. The severity of the disease was assessed using the using the Unified Parkinson\`s Disease Rating Scale insert ignore into journalissuearticles values(UPDRS);, while the stage of the disease was determined using modified Hoehn &Yahr Rating Scale insert ignore into journalissuearticles values(m HYRS);. Various measures were taken to evaluate the patients’ well-being, including the Beck Depression Inventory insert ignore into journalissuearticles values(BDI);, Beck Anxiety Inventory insert ignore into journalissuearticles values(BAI);, Pittsburgh Sleep Quality Index insert ignore into journalissuearticles values(PSQI);, Epworth Sleepiness Scale insert ignore into journalissuearticles values(ESS);, Parkinson\`s Disease Quality of Life Questionnaire insert ignore into journalissuearticles values(PDQ-39);, and Impact of Events Scale insert ignore into journalissuearticles values(IES-R); scores. The researchers also recorded the UPDRS scores, levodopa equivalent doses insert ignore into journalissuearticles values(LED);, and BMI of the patients before and after the lockdown period. Subsequently, the collected data were compared to identify any significant changes. Results: The difference in UPDRS, LED and BMI of the patients before and after the lockdown was statistically significant insert ignore into journalissuearticles values(p<0.05);. Furthermore, there was a significant increase in UPDRS motor score, BAI, and PDQ-39 values among female patients compared to male patients insert ignore into journalissuearticles values(p<0.05);. Comparing patients with and without COVID-19 infection, it was observed that patients who had contracted COVID-19 demonstrated a statistically significant increase in m HYRS and UPDRS motor scores, and PDQ-39 values after the lockdown insert ignore into journalissuearticles values(p<0.05);. To assess the impact of various factors on the quality of life, multiple linear regression analysis was performed. The analysis revealed that COVID-19-positive patients and female patients experienced a more pronounced effect on their quality of life insert ignore into journalissuearticles values(p<0.05);. Moreover, quality of life was found to be affected by disease stage, depression, anxiety, the IES-R scores increase, as well as by deteriorating sleep quality insert ignore into journalissuearticles values(p<0.05);. Conclusion: During the COVID-19 pandemic, PD patients experienced a worsening of clinical symptoms and increased treatment requirements. Furthermore, their quality of life was negatively affected, particularly among females and those who contracted COVID-19 infection. It is crucial to develop supportive treatment strategies targeting neuropsychological symptoms, as these could greatly contribute to the overall management and well-being of PD patients.
Keywords : Parkinsons disease, COVID 19, quality of life, sex