The relationship between osteoporosis and non-dipper hypertension in postmenopausal women

Authors : Tolga ÇAKMAK, İskender KADİFE, Erkan AYHAN, Turgay IŞIK

Pages : 898-904

View : 44 | Download : 41

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Aims: Previous studies have shown association between hypertension and osteoporosis, however has not been evaluated alterations of circadian blood pressure patterns. The present study investigated the effects of osteoporosison the circadian blood pressure assessed by ambulatory blood pressure monitoring. Methods: 68 patients insert ignore into journalissuearticles values(mean age: 61.3±8.7 years, 34 dipper and 34 non-dipper patients); with postmenopausal hypertension insert ignore into journalissuearticles values(HT); were prospectively enrolled in this study. Ambulatory blood pressure monitoring was performed on all patients. We measured bone mineral density insert ignore into journalissuearticles values(BMD); and T-score by dual X- ray absorptiometry at the lumbar spine. The receiver operating characteristics insert ignore into journalissuearticles values(ROC); curve was used to demonstrate the sensitivity and specificity of lumbar spine BMD, optimal cut - off value for predicting non-dipper hypertension insert ignore into journalissuearticles values(NDHT);. Results: T-score and BMD in non-dipper patients were lower than the dipper patients. There was a significant correlation between the rate of fall in night of mean blood pressure and both lumbar spine T-score and lumbar spine BMD insert ignore into journalissuearticles values(r= 0.330 and P =0.006 vs r=0.322 and P =0.007, respectively);. A lumbar spine BMD <0.944 g/cm2 measured by DXA had a 64.7% sensitivity and 64.7% specificity in predicting non-dipper hypertension at ROC curve analysis. Conclusion: Low lumbar spine BMD is an independent and strong predictor of non-dipper hypertension. Osteoporosis may be an indicator of cardiovascular risk. Therefore, osteoporotic patients should be treated more aggressively.
Keywords : Menopause, non dipper hypertension, osteoporosis