Assessment of vitamin D deficiency and hyperparathyroidism in metabolically healthy and unhealthy obese patients

Authors : Nergis AKBAŞ, Emin AKBAŞ

Pages : 968-973

View : 38 | Download : 47

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Aims: This study aimed to compare the levels of vitamin D in metabolically healthy insert ignore into journalissuearticles values(MHO); and metabolically unhealthy obese insert ignore into journalissuearticles values(MUO); individuals and determine if there are differences between these two groups concerning vitamin D deficiency and hyperparathyroidism. Methods: A total of 263 obese female patients were included in the study and divided into two groups based on metabolic syndrome diagnostic criteria. Biochemical and anthropometric data obtained after a 12-hour fasting period were analyzed. Results: Among the patients, the average 25-OH vitamin D level was 10.9±6.5 ng/ml. A total of 242 patients insert ignore into journalissuearticles values(92%); had vitamin D deficiency, and 132 patients insert ignore into journalissuearticles values(50.2%); were diagnosed with hyperparathyroidism. Significant differences were found in vitamin D insert ignore into journalissuearticles values(p=0.003); and uric acid insert ignore into journalissuearticles values(p<0.001); levels between the MHO and MUO groups. Additionally, the groups with vitamin D deficiency showed significantly different glucose insert ignore into journalissuearticles values(p=0.026); and homeostatic model assessment for insulin resistance insert ignore into journalissuearticles values(p=0.042); values. Patients with hyperparathyroidism had higher waist circumference insert ignore into journalissuearticles values(p<0.001);, waist-to-hip ratio insert ignore into journalissuearticles values(p=0.018);, BMI insert ignore into journalissuearticles values(p=0.006);, and systolic insert ignore into journalissuearticles values(p=0.001); and diastolic insert ignore into journalissuearticles values(p<0.001); blood pressure values compared to those with normal parathyroid hormone levels. Conclusion: The study emphasizes the importance of monitoring vitamin D deficiency and hyperparathyroidism in obese patients, as these conditions are more prevalent in this population and might be associated with metabolic syndrome parameters, increasing cardiometabolic risk.
Keywords : Vitamin D deficiency, obesity, hyperparathyroidism, metabolic syndrome, cardiovascular disease