Evaluation of the relationship between mitral annular calcification and triglyceride-glucose index

Authors : Gökhan GÖKALP, Nail Burak ÖZBEYAZ, Murat Oguz ÖZİLHAN

Pages : 1114-1118

View : 31 | Download : 37

Publication Date : 2023-09-28

Article Type : Research Paper

Abstract :Aims: Mitral annular calcification insert ignore into journalissuearticles values(MAC); is an echocardiographic condition with a multicomponent etiopathogenesis, one of which is insulin resistance. Triglyceride-glucose insert ignore into journalissuearticles values(TyG); index is an excellent biochemical parameter that has proven itself in determining insulin resistance in recent years. This study aims to reveal the relationship between the TyG index and the presence of MAC. Methods: The study included 159 patients with MAC and 167 control group. The control group has similar demographic characteristics such as age, gender, presence of hypertension insert ignore into journalissuearticles values(HT);, and diabetes mellitus with the MAC group. TyG index was calculated as a formula: ln[fasting triglyceride insert ignore into journalissuearticles values(mg/dl); × fasting plasma glucose insert ignore into journalissuearticles values(mg/dl);/2]. Results: The mean age of the patients was 74.2 and 48.2% of the patients were male. Coronary artery disease insert ignore into journalissuearticles values(CAD); insert ignore into journalissuearticles values(p: 0.031);, glucose insert ignore into journalissuearticles values(p:0.001);, total cholesterol insert ignore into journalissuearticles values(p:0.009);, low-density lipoprotein insert ignore into journalissuearticles values(LDL); insert ignore into journalissuearticles values(p:0.004);, triglyceride insert ignore into journalissuearticles values(TG); insert ignore into journalissuearticles values(p <0.001); levels and TyG index insert ignore into journalissuearticles values(p <0.001); were higher in MAC group. In the multivariate regression analysis, TG insert ignore into journalissuearticles values(p:0.004); and TyG index insert ignore into journalissuearticles values(p<0.001); were found to be independent risk factors. As a result of the ROC analysis, the cut-off value for estimating MAC was found to be 8.81 [insert ignore into journalissuearticles values(sensitivity: 77.3%, specificity: 76.5%, AUC insert ignore into journalissuearticles values(95% CI); 0.756 insert ignore into journalissuearticles values(0.704-0.807); p<0.001);]. Conclusion: In this study, a high TyG index was found to be an independent risk factor for MAC. The TyG index was found to be a better biomarker than TG and glucose alone in predicting MAC. Further extensive studies are necessary to determine the importance and use of TyG in MAC.
Keywords : Mitral annular calcification, insulin resistance, triglyceride glucose index