Clinical significance of pretreatment De Ritis ratio in renal cell carcinoma

Authors : Engin Kölükçü, Fatih Fırat, Kenan Yalçın, Şerifali Yağan Balcı, Yunus Emre Kuyucu

Pages : 247-251

Doi:10.32322/jhsm.1451075

View : 59 | Download : 58

Publication Date : 2024-05-27

Article Type : Research Paper

Abstract :Aims: This study aimed to investigate the relationship between pretreatment De Ritis ratio and Fuhrman nuclear grade and tumor stage in renal cell carcinoma (RCC). Methods: The data of 288 patients treated for RCC were analyzed. The De Ritis ratio was evaluated in patients classified by Fuhrman nuclear grade and tumor stage. The De Ritis ratio between groups was compared using Levene’s test. Results: A total of 145 patients (50.3%) were women female. Their mean age, aspartate aminotransferase, alanine aminotransferase values, and De Ritis ratio were as follows, respectively: 60.32±12.65 years, 20.55±11.54 IU/L, 17.4±10.87 IU/L, and 1.34±0.75. The De Ritis ratio was 1.12±0.44 in the low stage group and 2.01±1.05 in the high stage group. According to the Fuhrman nuclear grading, the De Ritis ratio was 1.15±0.43 in the low grade group and 1.70±1.14 in the high grade group. There was a statisticallysignificant difference between the groups (p<0.001). Conclusion: The present study showed high preoperative De Ritis ratio is significantly correlated with high tumor stage and Fuhrman nuclear grade in RCC.
Keywords : De Ritis ratio, transaminases, renal cell carcinoma, furhman grade