Immunology of Osteoporosis: A Short-Review

Authors : Volkan SUBAŞI

Pages : 48-52

Doi:10.5455/jicm.6.20160514

View : 21 | Download : 7

Publication Date : 2016-09-30

Article Type : Review Paper

Abstract :The osteoporosis pathogenesis is multifactorial and the immune system has an important role. Free radicals and the proteins or lipids that become glycated after exposure to sugars that may be related with bone resorption and inflammation. It is now recognized that the receptor activator of NF-κB ligand insert ignore into journalissuearticles values(RANKL); has a major role at the bone resorbing. The physiological receptor of the biological activity of RANKL is managed by osteoprotegerin insert ignore into journalissuearticles values(OPG);. The balance of RANKL and OPG in physiological bone turnover may control the bone density and pathological conditions.   This review aims to provide a short overview of osteoimmunology in osteoporosis .
Keywords : Osteoporosis, osteoimmunology, bone