Nutritional Indices and Cardiovascular Risk Factors in HIV Infection in Southern Nigeria

Authors : Augusta Chinyere NSONWU-ANYANWU

Pages : 34-42

Doi:10.5455/jicm.22.253019

View : 16 | Download : 6

Publication Date : 2017-06-30

Article Type : Research Paper

Abstract :Background: Viral load and specific drug related toxicities have been implicated in nutritional and metabolic disturbances in HIV infection. This study evaluated some micro, macro nutrients and cardiovascular risk factors in HIV infection with or without highly active antiretroviral therapy insert ignore into journalissuearticles values(HAART);. Material and Methods: Ninety subjects insert ignore into journalissuearticles values(18-65 years); comprising of 30 sero-positive HIV on HAART, 30 sero-positive HAART naïve and 30 HIV sero-negative subjects were recruited into the study. Fasting plasma glucose insert ignore into journalissuearticles values(FPG);, total proteins insert ignore into journalissuearticles values(TP);, albumin, vitamin C, total cholesterol insert ignore into journalissuearticles values(TC);, triglycerides insert ignore into journalissuearticles values(TG);, high density lipoprotein cholesterol insert ignore into journalissuearticles values(HDL-C); were estimated using colorimetric methods, zinc insert ignore into journalissuearticles values(Zn);, copper insert ignore into journalissuearticles values(Cu); by atomic absorption spectrophotometry, CD4+ T cell count by flow cytometry while body mass index insert ignore into journalissuearticles values(BMI);, globulin, atherogenic index of plasma insert ignore into journalissuearticles values(AIP);, albumin/globulin ratio insert ignore into journalissuearticles values(A/G);, very low density lipoprotein cholesterol insert ignore into journalissuearticles values(VLDL-C);, low density lipoprotein cholesterol insert ignore into journalissuearticles values(LDL-C); were calculated. Data were analyzed using ANOVA, LSD post hoc at p< 0.05. Results: HIV sero-negative subjects had higher BMI, CD4-T cell count, albumin, vitamin C, Zn, LDL-C, A/G ratio and lower FPG, globulin, Cu compared to HAART naïve; and higher BMI, CD4+T cell count, albumin, vitamin C, Zn with lower FPG, globulin, Cu, TG, and VLDLC compared to HIV on HAART respectively insert ignore into journalissuearticles values(p<0.05);. HIV on HAART had increased albumin, A/G ratio, FPG, LDLC, VLDL, TG, TC and lower CD4 +T cell count, TP, globulin and Zn compared to HAART naive subjects insert ignore into journalissuearticles values(p<0.05);. Conclusion: Disturbances in homeostasis of total proteins, antioxidant micronutrients with dyslipidemia and increased risk of cardiovascular disorders in HIV infection may be aggravated by HAART.
Keywords : HAART, HIV, lipid profile, micronutrients, proteins