Treatment Combinations and Prognosis in Multiple Resistant Acinetobacter baumannii and Carbapenem Resistant Klebsiella pneumonıae/oxytoca Isolates

Authors : Ahmet DOĞAN, Yakup GEZER

Pages : 121-128

View : 11 | Download : 8

Publication Date : 2021-10-30

Article Type : Research Paper

Abstract :Multi-drug-resistant insert ignore into journalissuearticles values(MDR); gram-negative bacterial infections are one of the most important causes of prolonged hospitalization and mortality in patients followed up in the İntensive Care Unit insert ignore into journalissuearticles values(ICU);. In our study, we retrospectively scanned the blood and tracheal aspirate cultures insert ignore into journalissuearticles values(TAC); of patients hospitalized in the ICUs of our hospital. We investigated the effects of demographic characteristics, comorbid conditions, treatment combinations and time of treatment on survival of 83 patients with MDR Acinetobacter baumannii and Klepsiella pneumoniae/oxytoca strains in culture samples from 450 cases. Of the patients, 48 insert ignore into journalissuearticles values(57.83%); were male, and 35 insert ignore into journalissuearticles values(42.17%); were female. Of all cases, the average age insert ignore into journalissuearticles values(years); was average±SD insert ignore into journalissuearticles values(Min-Max);, 76.24±13 insert ignore into journalissuearticles values(23-96);. Length of stay in intensive care, the average insert ignore into journalissuearticles values(day); was 25.61±19.1 insert ignore into journalissuearticles values(1-107);. Cerebrovascular Dısease insert ignore into journalissuearticles values(CVD); was the most common insert ignore into journalissuearticles values(20%); comorbidity. A. baumannii was grown in 31 insert ignore into journalissuearticles values(37.3%); patients, K. pneumoniae was grown in 50 insert ignore into journalissuearticles values(60.3%); patients, and K. oxytoca was grown in 2 insert ignore into journalissuearticles values(2.4%); patients. Age insert ignore into journalissuearticles values(p=0.793);, sex insert ignore into journalissuearticles values(p=0.429);, length of hospital stay insert ignore into journalissuearticles values(p=0.097);, number of comorbidities insert ignore into journalissuearticles values(p=0.553);, treatment combinations insert ignore into journalissuearticles values(p=0.727);, pathogen type insert ignore into journalissuearticles values(p=0.622);, growth in blood culture and/or TAC insert ignore into journalissuearticles values(p=0.369);, there was no statistically significant difference indicating that factors such as increased mortality. It was observed that intubation insert ignore into journalissuearticles values(p=0.004); and duration of treatment of 7 days or less insert ignore into journalissuearticles values(p=0.001); significantly reduced survival. In the treatment of MDR Acınetobacter and Klebsıella, ıntubatıon and duratıon of treatment affected survıval, but than combınatıon.
Keywords : multiple resistance, carbapenem resistant, acinetobacter baumannii, klebsiella pneumoniae oxytoca, colimycin, tigecycline