The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis

Authors : Erman SENEL, Enes OZKAN, Mehmet Cihan BEREKET, Mehmet Emin ONGER

Pages : 125-131

View : 15 | Download : 7

Publication Date : 2019-10-01

Article Type : Research Paper

Abstract :Purpose: This study aims to evaluate the effects of extracorporeal shock wave therapy applied before and/or immediately after the osteotomy on the maturation during the consolidation phase. Materials and Methods: 21 female New Zealand rabbits were used in the study. Subjects were divided randomly into three groups: Control insert ignore into journalissuearticles values(Distraction without ESWT);, A insert ignore into journalissuearticles values(Distraction +ESWT After Osteotomy);, AB insert ignore into journalissuearticles values(Distraction+ESWT After and Before Osteotomy);. ESWT insert ignore into journalissuearticles values(500 pulses, 5 Hz, 0.19 mJ/mm2 energy flux density); was applied to group A and group AB after 5, 12 and 19 days after osteotomy and group AB only on days 7,14 and 21 before osteotomy. On the 28th day of the consolidation period, all subjects were sacrificed. Dual-energy x-ray absorptiometry insert ignore into journalissuearticles values(DEXA); was used to determine bone mineral density insert ignore into journalissuearticles values(BMD); and bone mineral content insert ignore into journalissuearticles values(BMC);, and stereological methods were used to determine the new bone, connective tissue and neovascularization volumes. Results: As a result of DEXA examinations made on the 1st and 4th week of consolidation, there was no significant difference between groups regarding BMD and BMC values. According to the results of stereological examination, when the connective tissue and new bone tissue were evaluated, higher values were observed in AB when compared to A, and in AB and A compared to the control group, but the differences are not statistically significant. There was no difference between the groups in terms of neovascularization. Conclusion: ESWT in these parameters was not positively effective in bone maturation during consolidation when applied before osteotomy or both before and after osteotomy.
Keywords : bone regeneration, distraction osteogenesis, dual energy x ray absorptiometry, extracorporeal shock wave therapy, organ volume