Cardiovascular risk assessment with pulse wave velocity, intima media thickness, and flow-mediated dilatation in patients with idiopathic pulmonary fibrosis

Authors : Mehmet Sait ALTINTAŞ, Yasin YÜKSEL, Deniz DEMIRCI, Taskin RAKİCİ, Baris DEMİRKOL, Turgut KARABAĞ, Erdoğan ÇETİNKAYA

Pages : 176-182

Doi:10.47582/jompac.1257975

View : 11 | Download : 7

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: The underlying mechanism of fibrotic lung diseases predisposing to coronary artery disease is not yet clear. Chronic inflammation may contribute to atherosclerosis and play a role in increased cardiovascular risk. To study investigate subclinical atherosclerosis by measuring carotid femoral pulse wave velocity insert ignore into journalissuearticles values(PWV);, carotid intima media thickness insert ignore into journalissuearticles values(CIMT);, and flow-mediated dilatation insert ignore into journalissuearticles values(FMD); in patients with idiopathic pulmonary fibrosis insert ignore into journalissuearticles values(IPF);. Material and Method: This cross-sectional study consisted of 55 newly diagnosed IPF patients and 55 healthy controls between September 2019 and September 2021. Cardiovascular Risk Assessment was evaluated by endothelial function measured by FMD, CIMT measured by carotid doppler ultrasonography, and arterial stiffness measured by PWV. Results: In multivariable regression models, the presence of IPF was common independent predictor of CIMT insert ignore into journalissuearticles values(β±SE=0.18±0.05, p=0.002);, loginsert ignore into journalissuearticles values(FMD); insert ignore into journalissuearticles values(β±SE=–0.15±0.04, p<0.001); and loginsert ignore into journalissuearticles values(PWD); insert ignore into journalissuearticles values(β±SE=0.16±0.03, p<0.001);. An increase loginsert ignore into journalissuearticles values(PWV); levels were common independent predictors of CIMT and loginsert ignore into journalissuearticles values(FMD);. The levels of CRP were positively correlated with CIMT insert ignore into journalissuearticles values(r=0.359, p=0.009); and PWV insert ignore into journalissuearticles values(r=0.338, p=0.018); levels, while it was negatively correlated with FMD levels insert ignore into journalissuearticles values(r=-0.372, p=0.004);. Conclusions: IPF patients have elevated risk of endothelial dysfunction and atherosclerosis. A sustained inflammatory response may have play an important role in the process of atherosclerosis.
Keywords : kardiyovasküler hastalık, koroner arter hastalığı, pulmoner fibroz, ateroskleroz