Factors affecting the progression of chronic kidney disease

Authors : Raziye YAZICI, İbrahim GÜNEY

Pages : 207-210

View : 12 | Download : 23

Publication Date : 2023-06-28

Article Type : Research Paper

Abstract :Aims: Chronic kidney disease insert ignore into journalissuearticles values(CKD); is characterized by irreversible and progressive loss of renal function. One of the most important goals in CKD management is to delay CKD progression. The aim of this study was to investigate the outcomes of non-dialysing CKD patients, rate of progression of disease and factors associated with CKD progression and mortality. Methods: In this retrospective study, 245 non-dialysis CKD insert ignore into journalissuearticles values(stage 3-5); patients who presented to nephrology outpatient clinic between December 2013 and June 2015 were included. Patients’ baseline demographic, clinical/laboratory data were obtained. Outcomes of the patients in terms of CKD progression insert ignore into journalissuearticles values(defined as the initiation of renal replacement therapy or death); between November 2022 and December 2022 were recorded. Results: Patients’ mean age insert ignore into journalissuearticles values(baseline); was 56±12 years; 116 patients insert ignore into journalissuearticles values(47.3%); were female. During median 46 months of follow-up period, 42.9% of the patients underwent renal replacement therapy and all-cause mortality rate was 9.8%. Baseline eGFR, proteinuria and having diabetes mellitus as a comorbidity were found to be associated with CKD progression, independently insert ignore into journalissuearticles values(the risk increases by 75% with each 1 ml/min decrease in eGFR, p<0.001; the risk increases approximately 1.8 times with each 1 gr/day increase in proteinuria, p=0.003; the risk increases approximately 3 times with diabetes mellitus, p=0.043);. Conclusion: Our findings showed that baseline eGFR level, having diabetes mellitus and baseline proteinuria values were independent risk factors associated with disease progression and mortality in non-dialysing CKD patients. Early diagnosis and close monitoring of CKD, applying interventions targeting risk factors associated with CKD progression should be considered to delay CKD progression.
Keywords : Kronik böbrek hastalığı, progresyon, renal replasman tedavisi, risk faktörleri