Prospective examination of Tp-e interval and Tp-e/QT ratio in breast cancer patients receiving radiation therapy

Authors : Necla GÜRDAL, Gizem COSGUN, Binnur DONMEZ YILMAZ, Ahmet GURDAL

Pages : 362-367

Doi:10.47582/jompac.1302914

View : 31 | Download : 35

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Aims: The aim of this prospective study was to investigate ventricular repolarization using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in breast cancer patients treated with adjuvant radiotherapyinsert ignore into journalissuearticles values(RT); following systemic chemotherapy. Methods: The study was designed as a national, single-center prospective study. According to the treatment protocol, electrocardiograms insert ignore into journalissuearticles values(ECGs); were taken from all patients on their first and last days of RT. Tp-e intervals, Tp-e/QT ratios, and Tp-e/QTc ratios were calculated based on the ECG recordings. The heart doses due to radiation exposure were examined with mean heart dose, V5, V10,V20, and V30 values. Results: 51 postsurgical patients, who were all treated with AC followed by weekly paclitaxel and had an indication for adjuvant RT, were included in the study. The mean heart dose was observed as median 205 cGy, and the V30 value was 0.01%. When ECG measurements were analyzed, statistically significant increases were observed in Tp-e interval insert ignore into journalissuearticles values(p<0.001);, QT interval insert ignore into journalissuearticles values(p=0.007);, Tp-e/QT ratio insert ignore into journalissuearticles values(p<0.001);, and Tp-e/QTc ratio insert ignore into journalissuearticles values(p<0.001); at the end of RT. Additionally, positive correlations were observed between mean heart dose and post RT Tp-e insert ignore into journalissuearticles values(r= 0.770,p<0.01); and Tp-e/QTc ratio insert ignore into journalissuearticles values(r = 0.778,p<0.01); Conclusion: When compared to before RT, statistically significant prolongation of Tp-e interval and QT interval and increases in Tp-e/QT ratio and Tp-e/QTc ratio were detected which are thought to be predictive for ventricular repolarization process and ventricular rhythm disorders. In addition, the mean heart dose was positively correlated with Tp-e interval and Tp-e/QTc ratio.
Keywords : Meme Kanseri, Radyoterapi, Tp e Aralığı, Kardiyak toksisite, Tp e QT Oranı