Evaluation of the association of anti-thyroid peroxidase with antinuclear antibodies and different antinuclear antibodies patterns

Authors : Alper TOGAY, Banu Isbilen BASOK, Ayfer ÇOLAK, Nisel YILMAZ

Pages : 311-314

Doi:10.47582/jompac.1317134

View : 41 | Download : 48

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Aims: To investigate the relationship between anti-thyroid peroxidase insert ignore into journalissuearticles values(TPO);, a marker for Hashimoto’s thyroiditis, and antinuclear antibodies insert ignore into journalissuearticles values(ANA); and ANA patterns, biomarkers for systemic autoimmune diseases. Methods: In this study, ANA and anti-TPO test results, obtained in our hospital laboratory between 2019 and 2022, were retrospectively evaluated. ANA was detected by the indirect immunofluorescence antibody method using commercial HEp-20-10 cell substrates and anti-TPO was determined by the sandwich immunoassay method using a commercial immunoassay analyzer. Results: A total of 1750 patients’ results were analyzed. ANA was positive in 28.7% of anti-TPO-positive patients and 19% of anti-TPO-negative patients. While 6.4% insert ignore into journalissuearticles values(112/1750); of patients were positive for both ANA and anti-TPO, both test results were negative in 62.85% of patients insert ignore into journalissuearticles values(p<0.001);. When the ANA patterns’ distribution in patients with ANA and anti-TPO positivity examined together, the homogeneous pattern was statistically significantly higher than the other patterns insert ignore into journalissuearticles values(p=0.043);. Conclusion: Individuals with autoimmune thyroid disease had a higher rate of autoantibodies not only to thyroid-specific antigens but also to non-thyroid-specific antigens. Further studies are needed on how epigenetic changes, such as histone modifications might cause other autoimmune diseases and increase their frequency.
Keywords : ANA, Anti TPO, otoimmün hastalık, otoimmün tiroid hastalığı