Diagnostic performance of whole blood viscosity indices in predicting the presence and severity of coronary artery disease

Authors : Ahmet Kıvrak, Alp Yıldırım

Pages : 48-56

Doi:10.47582/jompac.1424294

View : 51 | Download : 89

Publication Date : 2024-02-29

Article Type : Research Paper

Abstract :Aims: Growing evidence suggests that blood viscosity plays a crucial role in both the development and acceleration of atherosclerosis. In this study, aimed to investigate the diagnostic performance of the mean platelet volume-age-total protein-hematocrit (MAPH) score, a new index for blood viscosity, in predicting the presence and severity of CAD in patients with suspected coronary artery disease (CAD). Methods: We retrospectively evaluated 431 patients who underwent coronary angiography. SYNTAX score (SS) were divided into 3 groups; low group ( 2 (sensitivity=78.2%, specificity=70.0%). It also had a graduated threshold value (>3, sensitivity=71.1%, specificity=62.5%) in distinguishing intermediate-high SS than low SS groups. In predicting both the presence and severity of CAD, the MAPH score exhibited superior diagnostic performance relative to the levels of LSR and HSR. Conclusion: In patients with suspected CAD, a gradual increase in the MAPH score demonstrated significant diagnostic performance in distinguishing both the presence and severity of CAD. In these patients, the MAPH score may serve as a potential screening tool and can be utilized for risk stratification.
Keywords : Kan viskozitesi, koroner arter hastalığı, MAPH skoru, mikrosirkülasyon, syntax skoru