KERATOCONUS TREATMENT: SOME PHYSICAL PARAMETERS OF DIFFERENT SOLUTIONS FOR CORNEAL CROSS-LINKING

Authors : Hilal Özdemir, N. Dağyar, Gülşen Evingür, F. Acar

Pages : 24-26

View : 5 | Download : 4

Publication Date : 2015-01-30

Article Type : Other Papers

Abstract :Cornea, the primary refractive element of the eye is a clear, transparent and elastic tissue that acts as a physical barrier between the external environment and the internal ocular elements. Cornea consists of five layers. Its Stroma layer is rich with proteins especially with collagen. Collagen is among the most abundant fibrous proteins and fulfils a variety of mechanical functions. When cross-links between the collagen fibers are weak, cornea will tend to thin and be deformed. This kind of eye disease is called Keratoconus. A unique treatment for Keratoconus is called corneal cross-linking insert ignore into journalissuearticles values(CLX);. During the CLX procedure the cornea is exposed to UV-A light and ribofilavin-dextran solution is instilled onto the cornea [1]. This treatment works by increasing collagen cross-links in the Stroma layer. CXL method has some problems which are explained in reference [2]. In this study, temperature and pH level change were examined for different solutions. Nine different solutions with varying concentrations were prepared by using riboflavin, dextran and dextrin substances. Behavior of these solutions at different temperatures and effectiveness of these concentrations according to eye`s pH level were investigated. Their absorption and fluorescence spectrum were also investigated in the critical concentration %0.1 insert ignore into journalissuearticles values(w/v); of riboflavin [3]. Their diffusion coefficients were found from the ratio of luminescence intensities measurement by using Fick’s Diffusion Law.
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