EASY SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN -2-(1H)-ONES USING PHOSPHATE FERTILIZERS MAP, DAP AND TSP AS EFFICIENT CATALYSTS

Authors : Sarra SIBOUS, Said BOUKHRIS, Rachida GHAILANE, Nouzha HABBADI, Amina HASSIKOU, Abdelaziz SOUIZI

Pages : 481-488

Doi:10.18596/jotcsa.286900

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Publication Date : 2017-03-06

Article Type : Research Paper

Abstract :A simple, efficient and green procedure has been developed for the synthesis of dihydropyrimidinones insert ignore into journalissuearticles values(Products of Biginelli); using phosphate fertilizers insert ignore into journalissuearticles values(mono-ammonium phosphate insert ignore into journalissuearticles values(MAP);, di-ammonium phosphate insert ignore into journalissuearticles values(DAP); and triple super phosphate insert ignore into journalissuearticles values(TSP);); as catalyst. The one-step reaction involved the three compounds, which are registered aromatic aldehydes, dicarbonyl compounds and the urea/thiourea. This new method provides some advantages such as obtaining excellent yields insert ignore into journalissuearticles values(98%);, as well as the short duration of the reaction, which may attain 2 min. These catalytic heterogeneous systems present also the advantage of being easily recycled.
Keywords : Heterogeneous catalysts, MAP, DAP, TSP, 3, 4 dihydropyrimidin 2 1H, ones