INTERRELATION AMONG SERUM LITHIUM LEVELS AND BONE METABOLISM AND SOME BIOCHEMICAL PARAMETERS IN PRE AND POST-MENAUPOSAL WOMEN

Authors : Ruken Esra DEMİRDÖĞEN, Fatih Mehmet EMEN, Derya KİLİC, Gokturk AVSAR, Tuncay YESİLKAYNAK, Tunay ASKAR

Pages : 491-500

Doi:10.18596/jotcsa.29558

View : 16 | Download : 6

Publication Date : 2017-01-08

Article Type : Research Paper

Abstract :The target of this study is to determine the interrelation among serum Li level on bone metabolism insert ignore into journalissuearticles values(Ca, P, Parathormon, and Vitamin-D);, sex and metabolic hormones insert ignore into journalissuearticles values(estrogen, FSH, LH and TSH);, and some biochemical parameters in premenopausal and postmenopausal women. The study is carried out with 10 women: 5 premenopausal and 5 postmenopausal women. The serum Li levels, bone metabolism indicators insert ignore into journalissuearticles values(i.e., ALP, Ca, P, Mg, Cu, Zn); and some biochemical parameters such as serum tryglyceride, alkalene phosphatase, total cholesterol, HDL, LDL and cholesterol levels were determined. The estrogen blood level of women in menopause period was found to be lower than that of women in pre-menopause period insert ignore into journalissuearticles values(p<0.01); and the FSH level was found to be higher insert ignore into journalissuearticles values(p<0.01);. In the lipid profile the triglyceride level in the post-menopause period was found to be low insert ignore into journalissuearticles values(p<0.05); and HDL insert ignore into journalissuearticles values(p<0.001);, LDL insert ignore into journalissuearticles values(p<0.001); and the cholesterol levels were found to be high insert ignore into journalissuearticles values(p<0.001);. The alkalene phosphatase insert ignore into journalissuearticles values(p<0.001); and Vitamin-D levels insert ignore into journalissuearticles values(p<0.001); were found to decrease. When the mineral levels were investigated no meaningful difference was observed in the serum magnesium and copper levels while zinc insert ignore into journalissuearticles values(p<0.01); and phosphorus insert ignore into journalissuearticles values(p<0.005); levels were observed to increase, the calcium levels insert ignore into journalissuearticles values(p<0.05); decreased and Li levels considerably decreased insert ignore into journalissuearticles values(p<0.0001);. According to the results obtained it was determined for the first time that Li defficiency can be related with menopause and the related diseases and thus Li therapy can be used in developing new treatment protocols of menopause as an alternative method.
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