Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities

Authors : Yusuf Oloruntoyin Ayipo, Joshua Ayoola Obaleye, Umar Muhammad Badeggi

Pages : 313-326

Doi:10.18596/jotcsa.287331

View : 14 | Download : 3

Publication Date : 2017-01-09

Article Type : Research Paper

Abstract :Synthesis of coordination compounds of Zincinsert ignore into journalissuearticles values(II);, Copperinsert ignore into journalissuearticles values(II);, Nickelinsert ignore into journalissuearticles values(II);, Cobaltinsert ignore into journalissuearticles values(II); and Ironinsert ignore into journalissuearticles values(II); with mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid has been studied. The complexes were characterized via: solubility test, melting point determination, conductivity measurement, Atomic Absorption Spectroscopy, UV-Visible Spectroscopy, FTIR Spectroscopy and magnetic susceptibility. The complexes were proposed to have a stoichiometry ratio of 1:1:1 between each metal salt and the ligands with tetrahedral and octahedral geometry following the reaction pattern of MX.yH 2 O + L 1 L 2/3 to give ML 1 L 2/3 X.yH 2 O. Biologica l activities of the synthesized complexes have been evaluated against Escherichia coli and Staphylococcus aureus .
Keywords : Antimalaria, Analgesic, Mixed ligands, Metal complexes, Spectroscopy, Biological activities